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PT I - Med Chem > PI & PII Reactions > Flashcards

PI & PII Reactions Flashcards

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1
Q

List the PI CYP450 oxidation reactions

A 
aliphatic & aromatic hydroxylation
N-dealkylation, N-oxide
O-dealkylation
S-dealkylation
oxidative deamination
dehalogenation
epoxidation
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2
Q

List the PI non-CYP450 oxidation enzymes

A 
ADH (alcohol dehydrogenase)
ALDH (aldehyde dehydrogenase)
XO (xanthine oxidase)
MAO (monoamine oxidase)
FMO (flavin-containing monooxygenase)
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3
Q

List the PI reduction reactions

A

azo
nitro
misc.

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4
Q

List the PI hydrolysis enzymes

A

carboxyesterase

EH (epoxide hydrolase)

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5
Q

ADH & ALDH cofactor

A

NAD

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6
Q

MAO cofactor

A

FAD

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7
Q

FMO cofactor

A

flavin

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8
Q

List the PII reactions

A 
glucoronidation
sulfation
glutathione conjugation
acetylation
amino acid conjugation
methylation
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9
Q

Glucoronidation enzyme and cofactor

A

UGT (uridine diphosphate glucuronosyl transferase)

UDG acid

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10
Q

Sulfation enzyme and cofactor

A

SULT (sulfotransferase)

PAPs

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11
Q

Glutathione conjugation enzyme and cofactor

A

GST (glutathione S-transferase)

GSH

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12
Q

Acetylation enzyme and cofactor

A

NAT1 or 2 (N-acetyltransferase)

Acetyl-CoA

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13
Q

Amino acid conjugation enzyme and cofactor

A

acylsynthetase

Acetyl-CoA

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14
Q

Methylation enzyme and cofactor

A

methyltransferase (COMT, TPMT, PNMT, TMT)

SAM (methyl donor)

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PT I - Med Chem (4 decks)

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