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Ocular Phys Block 11 > Physiology Or RPE And Retinal Blood Barrier > Flashcards

Physiology Or RPE And Retinal Blood Barrier Flashcards

1
Q

Apical side of RPE

A

Photoreceptor side

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2
Q

Basal side of RPE

A

BM of RPE from Bruchs

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3
Q

Where does general light absorption occur

A

Melanin in RPE

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4
Q

Blue light absorption

A

Supplemented by late in and zeaxanthin in photoreceptors

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5
Q

Most dangerous light for RPE

A

Blue light

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6
Q

Outer retina exposed to

A

Oxygen rich enovironment

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7
Q

Outer retina and oxidative damage

A

Susceptible to it since it is in the presence of the choriocapillaris blood supply

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8
Q

Line of defense against oxidative damage to the retina

A

RPE

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9
Q

Transepithelial transport RPE

A
  1. Transport from photoreceptors to blood

2. Transport from blood to the photoreceptors

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10
Q

Apical side of RPE

A

Photoreceptors (subretinal space between RPE and photoreceptors)

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11
Q

Basolateral side of RPE

A

Blood

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12
Q

Removal of water from apical side

A

The transport of water is driven by an active transport of Cl- from the retina to blood side

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13
Q

What happens when going from photoreceptors to blood

A
  1. Removal of water from apical side

2. Removal of lactic acid from apical side

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14
Q

Degeneration of RPE, bulls eye shaped lesion, the lesion primarily contains extracellular fluid. Caused by reduction in epithelial Cl- transport

A

Best’s Vitelliform macular degeneration

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15
Q

Transport of lactic acid from RPE

A

Requires a tight regulation of the intracellular pH

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16
Q

What transports nutrition from blood to photoreceptors?

A

RPE

17
Q

Transports and RPE

A

Contains a lot of transporters to transport glucose to the photoreceptors

18
Q

Things the RPE can transport into the photoreceptors

A

All-trans-retinol, glucose, DHA

19
Q

Visual cycle

A
  • reduction of all-trans-retinal into all-trans-retinol occurs in photoreceptors
  • reisomerization of all-trans-retinol into 11-cis-retinal
  • occurs in RPE
20
Q

Where does reduction of all-trans-retinal happen

A

Photoreceptors

21
Q

Here does reisomerixation of all-trans-retinol occur

A

RPE

22
Q

Inherited retinal degeneration caused by mutations in genes of the visual cycle

A

Retinitis pigmentosa

23
Q

Retinal degeneration caused by mutations int he genes of the visual cycle

A

Stargardt disease

24
Q

The process of phagocytosis is under what control

A

Circadian

25
Q

When is phagocytosis at its peak in the RPE

A

Morning

26
Q

Every RPE cell is facing an average of ______ photoreceptors in the fovea

A

23

27
Q

Inability of the RPE to phagocytosis photoreceptors outer segment

A

RP

28
Q

What does RPE secrete into the photoreceptors

A

PEDF
VEGF
Other growth factors
Cytokines or immune modulators

29
Q

VEGF in healthy eyes

A

Secreted in low concentrations

30
Q

What is essential for maintenance of the structural integrity of retina?

A

Other factors (not PEDF or VEGF)

31
Q

The most severe complication in age related macular degeneration. RPE cells secreted VEGF at a higher rate compared with RPE cells from eyes without neovasculariation

A

Choroidal neovascularisation

32
Q

Retinal blood barrier

A

Retinal vascular endothelium

Tight junction between retinal pigment epithelium

33
Q

Which option stand for apical side, basolateral side of RPE

A

Photoreceptor, choriocapillaris

34
Q

Which option absorbs blue light

A

Lutein and zeaxanthin

35
Q

Which one is driving force to remove water from apical side

A

Active transport of Cl- from retina to blood

36
Q

Where does reisomerization of all-trans-retinol into 11-cis-retinal occur

A

RPE

37
Q

Which disease is due to reduction of epithelia Cl- transport

A

Bests vitelliform macular degeneration

38
Q

Which growth factor gets involved in choroidal neovascularization

A

VEGF

Ocular Phys Block 11 (6 decks)

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