physiology of taste and smell Flashcards

1
Q

where does the tongue develop embryology

A

develops in the back of the neck in occipital somites
mesoderm = muscle
ectoderm = surface, branchial arch

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2
Q

what develops from the first brachial arch

A

tuberculum midline and lateral lingual swellings
from the mucosal surface of the anterior 2/3 of the tongue
trigeminal nerve (CN V) for touch and pain; facial nerve (CN VII) for taste

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3
Q

what develops from the third brachial arch

A

cupula (hypobranchial eminence)
forms the posterior 1/3 of the tongue (pharyngeal tongue)
glossopharyngeal nerve (CN IX)

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4
Q

what develops from the mesoderm in the upper neck (occipital somites)

A

intrinsic and extrinsic muscles
hypoglossal nerve (CN XII)

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5
Q

what are the extrinsic muscle of the tongue

A

genioglossus, hyoglossus and styloglossus
- with palatoglossus, moves tongue back forwards up and down

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6
Q

what are the intrinsic muscles of the tongue

A

vertical, horizontal and longitudinal

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7
Q

what are the 5 primary taste

A

sour
salty
sweet
bitter
savoury/ umami

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8
Q

what chemicals create sour

A

acid, H+

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9
Q

what chemicals create salty

A

Na+

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10
Q

what chemicals create sweet

A

glucose

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11
Q

what chemicals create bitter

A

coffee, beer, quinine, blue cheese, olives

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12
Q

what chemicals create savoury/ umami

A

glutamate

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13
Q

what is the purpose of bitter taste

A

bitterness is the most sensitive and has a protective function
- protects against poison ingestion
- children will not eat bitter things, but you can train yourself to like them

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14
Q

what innervates the anterior 2/3 of the tongue

A

lingual nerve (trigeminal, CN V)
chorda tympani (facial, CN VII)

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15
Q

what innervates the posterior 1/3 of the tongue

A

glossopharyngeal (CN IX)

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16
Q

what innervates the solitary nucleus of the medulla

A

gustatory cortex (anterior insula + inferior frontal gyrus)
thalamus

17
Q

what are the other sensory inputs involved in flavour

A

pungency - pain/ temperature receptors
coolness (menthol) - temperature receptors
fattiness - controversial
temperature - enhances release of odorants to the nose
texture - crunchy/ creamy

18
Q

how can ear surgery affect taste

A

ear surgery can cause damage to the chorda tympani
- unilateral - minimal symptoms
- bilateral - unpleasant metallic taste in mouth

19
Q

what surgery can damage the lingual nerve

A

surgery to sublingual and submandibular salivary glands
- unilateral loss of taste and loss of common sensation in the floor of the mouth and tongue

20
Q

how does dry mouth arise

A

autoimmune diseases
radiotherapy to head and neck
drugs
nothing to dissolve chemicals in

21
Q

describe the structure of the nose

A

horizontal structure 7cm long
warms and humidifies incoming air

22
Q

what creates quiet breathing

A

laminar airflow over the inferior turbinate (projections with thick vascular mucosa)

23
Q

what happens to air in sniffing

A

turbulence to mix the air and send odorants to the roof of the nose
- olfactory mucosa sits just below cribriform plate, olfactory bulbs just above
- cribriform plate is very thin + fragile DONT POKE THINGS DIRECTLY UPWARDS IN THE NOSE

24
Q

how are odorant molecules detected

A

dissolve in nasal mucus
detected by rhodopsin-like detectors on dendrites of olfactory
each receptor responds to more than one odorant (based on molecular shape, size, polarity, charged groups
each odorant stimulates more than one receptor

25
Q

where does the olfactory nerve (CN I) project to

A

amygdala
hippocampus -> memory, why is smell so evocative and plays a large role in attraction
- attempts to find people with different genetic makeup (different immune system)
parahippocampal gyrus

26
Q

how is congenital anosmia acquired

A

Kallmann syndrome (hypogonadotropic hypogonadism)
rhinosinusitis
neurological disorders (Alzheimer’s, Parkinson’s, MS)
base of skull fracture
brain tumour
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