Physiology Khogali session 1 Flashcards

1
Q

what is functional residual capacity

A

the volume remaining in the lungs after a normal, passive exhalation

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2
Q

what is vital capacity

A

the maximum volume of air that can be exhaled after a maximum inspiration

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3
Q

functional vital capacity is normally about __% of total lung capacity

A

40

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4
Q

what is total lung capacity

A

the maximum volume of air that the lungs can hold at the end of maximum inspiration

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5
Q

what is FEV1/FVC% in a patient with pulmonary fibrosis likely to be

A

85% - because restrictive pattern, both FEV1 and FVC are reduced so ratio doesn’t drop

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6
Q

normal FEV1/FVC ratio

A

> 75%

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7
Q

FEV1/FVC ratio in asthma

A

<75%

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8
Q

FEV1/FVC ratio in COPD even after bronchodilator

A

<70%

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9
Q

COPD spirometry confirmed diagnosis

A

FEV1/FVC ratio <70% even after bronchodilator

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10
Q

a low PO2 causes pulmonary vaso__________

A

vasoconstriction

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11
Q

why does heart failure affect pulmonary compliance

A

Heart failure occurs when the heart muscle doesn’t pump blood as well as it should. Blood often backs up and causes fluid to build up in the lungs and in the legs.

In pulmonary edema, liquid-filled alveoli induce mechanical stress on air-filled alveoli, reducing the compliance of air-filled alveoli, and hence overall lung compliance.

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12
Q

factors that decrease pulmonary compliance

A

pulmonary fibrosis
pulmonary oedema
lung collapse
pneumonia
absence of surfactant

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13
Q

dynamic airway compression

A

when we breathe in intrapleural pressure falls, when we breathe out intrapleural pressure rises

this pressure can compress the alveoli
intraairway pressure oppose intrapleural

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14
Q

which pressure opposes intrapleural pressure

A

intraairway

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15
Q

dynamic airway compression is likely to occur during active _______

A

expiration

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16
Q

why is it important to not give too much oxygen to COPD patients

A

excessive oxygen can lead to hypercapnaeic resp failure in COPD patients with chronic CO2 retention

excessive oxygen given to patients with COPD may
- increase V/Q mismatch by diverting blood flow to poorly ventilated alveoli
- increase the release of CO2 from oxygenated Hb. But COPD patients are unable to increase their ventilation to match the increase in CO2 retention

17
Q

what is emphysema

A

involves the gradual damage of lung tissue, specifically the destruction of the alveoli. destruction of the elastic component. problem with recoil (expiration)

18
Q

compliance vs recoil

A

compliance - how easy it is to stretch the lungs
recoil - the lung’s intrinsic tendency to deflate following inflation

compliance may become abnormally increased if the elastic recoil of the lungs is lost

19
Q

does emphysema cause increased or decreased compliance

A

increased

20
Q

what is the O2 content of arterial blood determined by?

A

the Hb concentration and the saturation of Hb with oxygen