Pharmacology Flashcards
pharmacokinetic vs pharmacodynamic
Pharmacokinetics is the study of what the body does to the drug, and Pharmacodynamics is the study of what the drug does to the body
modification of the action of one drug at the target site by another independent of a change in its concentration - is this pharmacokinetic or pharmacodynamic interaction
pharmacodynamic
furosemide can exacerbate gout, true or false
true
both thiazide and loop diuretics can cause drug-induced gout - less elimination of uric acid
can ACEi exacerbate gout
yes ACEi can cause drug-induced gout
muscle pains after grapefruit juice - which drug may cause this?
statin
is the interaction between simvastatin and grapefruit juice a pharmacokinetic or pharmacodynamic interaction?
pharmacokinetic
when would you avoid NSAIDs in treatment of acute gout
if the patient has renal failure
what is the HAS-BLED scoring system used for
risk of bleeding when the patient is on anticoagulation
what is CHAD scoring used for
thrombosis risk
before a hip surgery, would warfarin need to be stopped? if so, for how many days
yes, 5 days before surgery
what is the target INR around surgery
<= 1.5
spinal anaesthesia can cause ____tension
hypo
does ephedrine raise or lower BP
raises
bisoprolol and losartan can cause hyperkalaemia, true or false
true
(bisoprolol by itself isn’t a big risk, but together with other drugs can be)
plasma half-life of ciclosporin
27 hours
