Physiology

Question 1

What nociceptors are the first, fast and sharp response to pain?

Answer 1

Aß: Strong mechanical & thermal sensors

Question 2

What nociceptors are delayed, duller and longer-lasting second response to pain?

Answer 2

C fibers: unmyelinated = slow

Question 3

What are the 3 anterolateral pathways of pain?

Answer 3

1. Spinothalamic: To ventro-posterior lat (VPL) thalamus
   Conscious sensation
2. Spinoreticular: To reticular formation
   Affective motivational aspects of pain
3. Spinalmesencephalic: To periaqueductal gray and superior colliculi
   Central modulation

Question 4

How do NSAIDs work?

Answer 4

Inhibittion of prostaglandin synthesis through their effect on cyclooxygenase (COX)