Physiology Flashcards
Factors that promote juxtaglomerular secretion of renin
- Decreased pressure in renal afferent arterioles
- Decreased sodium delivery to macula densa of distal convoluted tubule
- Increased beta 1 noradrenergic stimulation to juxtaglomerular cells
Cranial nerve that transmits aortic arch information
Vagus nerve
Cranial nerve that transmits carotid sinus information
Glossopharyngeal nerve
Medullary nucleus that receives information from the baroreceptors
Solitary nucleus
Difference between Mobitz type 1 and 2 2nd degree AV block
Mobitz type 1 skips a beat after progressive prolongation of the PR Interval, while Mobitz type 2 skips it without this prolonged interval
Class 1 antiarrhythmics with potassium channel blocking effects
1A
Macroscopic changes after a myocardial infarction in day 1
- Dark mottling
* Pale with tetrazolium stain
Histologic changes after a myocardial infarction in 1 day
- Early coagulative necrosis (starts at 4 hours)
* Contraction bands
Macroscopic changes after a myocardial infarction in days 2 to 4
Hyperemia
Most abundant type of inflammatory cell after a myocardial infarction during days 2 to 4
Neutrophils
Postinfarction fibrinous percarditis is a common side effect during which period of time after a myocardial infarction
2 to 4 days
Macroscopic changes after a myocardial infarction in days 5 to 10
- Hyperemic border
* Central yellow-brown softening
Most abundant type of inflammatory cell after a myocardial infarction during days 5 to 10
Macrophages (formation of granulation tissue at margins)
Dressler syndrome occurs how long after a myocardial infarction
Weeks to months
Time it takes for troponin I to peak in plasma and how long does it stay elevated
Starts rising after 4 hours and peaks after 24 hours, stays elevated for 7 to 10 days
Time it takes for CK-MB to peak and how long does it stay elevated
Starts rising after 6 to 12 hours and peaks after 16 to 24 hours, stays elevated for 2 to 3 days
Cardiac enzyme that is the most useful in diagnosing a reinfarction
CK-MB
Cardiac malformation associated with congenital rubella
PDA
Cardiac malformation associated with a diabetic mother
Transposition of the great vessels
Treatment of HACEK group infections
- Third generation cephalosporins
* Fluoroquinolones
Jones criteria for rheumatic fever
Diagnosis requires 2 major or 1 major and 2 minor:
- Joint (migratory poloarthritis)
- Heart (carditis)
- Nodules in skin (subcutaneous)
- Erythema marginatum
- Sydenham corea
Minor: fever, arthralgias, elevated APR
Triad of Wegener’s granulomatosis (granulomatosis with polyangiitis)
- Focal necrotizing vasculitis
- Necrotizing granulomas in the lung and upper airway
- Necrotizing glomerulonephritis
Type of antibody associated with Wegener’s granulomatosis (granulomatosis with polyangiitis)
PR3-ANCA/c-ANCA (anti-proteinase 3)
Wegener’s granulomatisis (granuloamtosis with polyangiitis) treatment
Corticosteroids and cyclophosphamide
Main symptomatic difference between Wegener’s granulomatosis and microscopic polyangiitis
In microscopic polyangiitis there’s no nasopharyngeal involvement and no granulomas
Type of antibody associated with microscopic polyangiitis
MPO-ANCA/p-ANCA (anti-myeloperoxidase)
Pathologic and laboratory characteristic of Churg-Strauss syndrome
- Granulomatous, necrotizing vasculitis
* Eosinophilia
Type of cell necessary for truncus arteriosus partition
Neural crest cells
Failure in truncus arteriosus partition can give rise to what pathologies
- Transposition of the great vessels
- Tetralogy of Fallot
- Persistent truncus arteriosus
The outflow tract of the ventrciles is derived from which embryonic structure
Bulbus cordis
The coronary sinus is derived from which embryonic structure
Left horn of sinus venosus
The smooth part of the atrium is derived from which embryonic structure
Right horn of sinus venosus