Physiology Flashcards

1
Q

What is villi?

A

finger like projection about 1mm in height

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2
Q

Where can intestinal glands (crypts of lieberkuhn) be found ?

A

Between the bases of the villi

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3
Q

intestinal glands secret

A

intestine juice

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4
Q

Brunner,s glands are found in the submucosa of

A

the duodenum

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5
Q

peyer,s patches are

A

aggregated Lymphoid tissue found in the ileum

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6
Q

the lining epithelial cells In the crypts are?(4)

A
  1. Undifferentiated, actively dividing cells
  2. Mucus-secreting goblet cells
  3. Various epithelial endocrine cells
  4. Paneth cells containing large eosinophilic granules, also contain lysozyme immunoglobulins
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7
Q

The epithelial cells lining the villi include?(3)

A
  1. The digestive absorptive columnar cells with brush border, called enterocytes
  2. Mucus secreting goblet cells
  3. A few endocrine epithelial cells
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8
Q

Actively proliferating cells in the crypts migrate on to the villus to become?

A

enterocytes

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9
Q

The microvilli of enterocytes are covered by

A

layer of glycocalyx (complex of polysaccharide & protein)

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10
Q

Brunner,s glands in the duodenum secrete ?

A

alkaline fluid that contains mucus but not enzymes

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11
Q

Intestinal juice is a turbid fluid with a fishy odour

A

No answer here

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12
Q

Enteropeptide activates …… to …..

A

trypsinogen to trypsin

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13
Q

Large intestine Differs from the small intestine in ?(5)

A

➢No No villivilli.
➢Higher number of goblet cells.Higher number of goblet cells.
➢Higher number of intestinal bacteria.Higher number of intestinal bacteria.
➢Have haustra in its wall.
➢ Presence of teniaeteniae coli (incomplete outer longitudinal smooth muscle in its wall)

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14
Q

INTESTINAL MOTILITY have Two types ?

A

1.Preistalsis : pushes food forward, 2.Segmentation (Mixing): mixes food with enzymes and exposes it to the intestinal surface for absorption .

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15
Q

pacemaker found in?

A

In the duodenum just above the opening of bile & pancreatic ducts .

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16
Q

small-bowel slow waves are called?

A

basal electric rhythm (BER),

17
Q

BER

A

These are are spontaneous cyclic waves of smooth muscle depolarization & repolarization which are responsible for the coordination of intestine movements

18
Q

BER

A

These are are spontaneous cyclic waves of smooth muscle depolarization & repolarization which are responsible for the coordination of intestine movements

19
Q

Their frequency declines as they move

20
Q

Segmentation contraction is

A

ring-like contractions of the circular muscle layer appear at regular intervals

21
Q

The segmentation contraction may also have propulsive effect on contents

A

No answer here

22
Q

Segmentation persist after ……… denervation, but disappear after destroying the ……..

A

extrinsic

intrinsic nerve plexus

23
Q

Peristalsis is controlled by

A

intramural myenteric reflex

24
Q

It persists after …… denervation & is abolished after destruction of……

A

extrinsic

intrinsic nerves

25
What causes circular muscle above bolus to contract ?
1. The reflex is triggered by distension 2. leading to release of 5-HT 3. stimulates intrinsic afferent Ach & substance P
26
What causes the muscle at the bolus site & & below it to relax ?
Distending cholinergic interneurons | activate inhibitory motor neurons to release NO & VIP
27
Vagotomy and sympathectomy effects on intestinal movements?
Vagotomy is followed by transient hypomotility | sympathectomy does not affect intestinal movements
28
gastrin and CCK
stimulates intestinal motility
29
Motiline
stimulates intestinal motility & may be regulate interdigestive MMC activity
30
Secretin
inhibits intestinal motility & contracts the ileocaecal sphincter
31
Secretin family
SECRETIN VIP GIP Glucagon
32
SECRETIN Mechanism of action is?
Secretin has cell membrane receptors. Its effects are mediated via the second messenger “cAMP
33
SECRETIN production is stimulated by ?
the products of protein digestion and by acid bathing the mucosa of the upper small intestine
34
SECRETIN secretion control
Negative feedback
35
gastrin family
gastrin | CCKPZ
36
CCKPZ is Produced by
I cells of the duodenum and by some neurons in the brain and GIT
37
SECRETIN is produced by ?
S cells in the duodenum
38
CCKPZ production is stimulated by?
Luminal amino & fatty acids (mainly) Low pH in the duodenum
39
CCKPZ Mechanism of action ?
Has cell membrane receptors. - Its effects are mediated via “phospholipase C