Physiological and Pathological Modelling in Neuroscience

Question 1

What are the main purposes of animal models of epilepsy?

Answer 1

Discovery of new AEDs Characterisation of spectrum anticonvulsant activity of new AEDs Specific models for pharmacoresistant seizures Evaluating whether efficacy of new AEDs changes during chronic treatment Comparison of the adverse effects of new AEDs in epileptic vs non-epileptic animals Estimation of the effective plasma concentrations of new AEDs for first clinical trials Discovery of antiepileptogenic or disease-modifying treatments

Question 2

Models of epilepsy or epileptic seizures