Physio (Review): Kidney Solute Processing, Sodium And Water Flashcards

1
Q

How do you calculate Filtration Fraction (FF)

A

FF = (GFR) / (RPF)

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2
Q

Autoregulation

A

Critical for the kidneys to keep GFR within a limited range

Arterial pressure fluctuations (80-180 mmHg) result in only small changes in GFR and RPF

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3
Q

Autoregulation becomes absent at MAP (mean arterial pressure) of ___________ mmHg

A

<70 mmHg

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4
Q

Autoregulation is a completely _____________ process

A

Intrarenal

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5
Q

What are the 2 mechanisms of autoregulation?

A
  1. Myogenic mechanism

2. Tubuloglomerular feedback

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6
Q

The Myogenic mechanism is intrinsic to the ____________ in the blood vessels

A

Vascular Smooth Muscle

Fast acting

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7
Q

Myogenic mechanism protects the glomeruli from short term __________

A

Pressure changes

You get contraction of the vascular smooth muscle in response to increase STRETCH

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8
Q

Increased blood pressure will increase passive wall tension….Which leads to an increase in ________

A

GFR and RPF

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9
Q

The myogenic mechanism is via stretch-activated increased in ____________ influx in vascular smooth muscle

A

Ca2+

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10
Q

A high GFR results in increased flow and increased Na+ delivery to the ______________

A

Macula Densa

The macula densa is part of the juxtaglomerular apparatus.

Senates flow and Na+ concentration

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11
Q

High flow/Na+ = release of ____________

A

ATP and Adenosine

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12
Q

Mesangial cell contraction = decreased_______________

A

Kf

Kf is the filtration coefficient

It is about equal to the glomerular surface area

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