Physio DSA Flashcards
Somatostatin
D cells of GI mucosa Stim by low luminal pH Actions: - inhibits gastric H+ secretion - inhibits other GI hormones
Also secreted by hypothalamus and delta cells of exo. Pancreas
Histamine
Enterochromaffin-like cells in gastric glands
Targets parietal cells to stim acid production
Gastrin
Increases H+ secretion by stim growth of gastric mucosa
CCK
Increases pancreatic enzyme secretion
Increases pancreatic HCO3- secretion
Stim contraction of GB and relaxation of Oddi
Stim growth of exo pancreas and GB (trophic effect)
Inhibits gastric emptying
Secretin
Increases pancreatic HCO3- secretion
Increases biliary HCO3- secretion
Decreases gastric H+
Inhibits trophic effect of gastrin on gastric mucosa
GIP
Stim by oral glucose!
Increases insulin secretion from pancreatic B cells (INCRETIN effect)
Decreases gastric H+ secretion
ACh
Cholinergic neurons
- Contraction of smooth mm. In wall
- Relaxation of sphincters
- Increases salivary/gastric/pancreatic secretion
NE
Adrenergic neurons
- Relaxation of smooth mm. In wall
- Contraction of sphincters
- Increases salivary secretion
VIP
Neurons of ENS
- Relaxation of smooth mm.
- Increases intestinal secretion
- Increases pancreatic secretion
NO
Neurons of ENS
Relaxation of smooth mm.
GRP
Vagal neurons of gastric mucosa
- Increases gastrin secretion
Enkephalins
Neurons of ENS
- Contraction of smooth mm.
- Decreases intestinal secretion
Neuropeptide Y
Neurons of ENS
- Relaxation of smooth mm.
- Decreases intestinal secretion
Substance P
Co-secreted with ACh by ENS
- Contraction of smooth mm.
- Increases salivary secretion
