Physio - Drugs

Question 1

Physostigmine: anti achetylcholinesterase

Answer 1

Prolonged post-synaptic response to ACh

Question 2

Conotoxin: blocks voltage-gated calcium channels

Answer 2

Prevents exocytosis of ACH

Question 3

Dendrotoxin: blocks voltage-gated K+ channels

Answer 3

Prevents repolarization of presynaptic membrane and increases release of ACh

Question 4

Tetrodotoxin: blocks voltage-gated Na+ channels (mechanism in lidocaine)

Answer 4

Prevents nerve and muscle action potentials

Question 5

Tetanus: blocks synaptic vesicle exocytosis in inhibitory interneurons (manifests in jaw first)

Answer 5

Produces skeletal muscle spasms

Question 6

Curare: blocks the acetycholine receptor

Answer 6

Produces flaccid paralysis