PHYSIO Flashcards
Volume of blood
5 litres out of 45 l of fluids
What is hematocrit
Volume percentage of RBCs in blood 45%
Why RBCs are more in men than in women?
The effect of androgens
The most abundant leukocyte
Neutrophils
PH of blood with changes
Normal range = 7.35 - 7.45
Lower =acidosis
Higher= alkalosis
Less than 6.8 and higher than 8 causes death because it affects the enzymes and denatures proteins and affect k+ hydrogen levels and CNS
Normal intracellular potassium percentage
98%
The more acidic ?
Venous blood
Where plasma proteins are produced
Generally in liver except for gamma globulins in lymphocytes
Main plasma proteins
Albumin
Globulin
Fibrinogen
Prothrombin
Plasma proteins
as building blocks of cells and tissues. They function
as enzymes, hormones, antibodies and transporters, they contribute to plasma
osmolarity and acid-base balance, they serve as an energy source under limiting
conditions
Complete proteins
Poultry fish eggs
Incomplete proteins
Causes amino acids deficiency
Volume of blood in heart
5%
Highest amount of blood in?
Veins
What raises blood volume
Sex, pregnancy, muscular exercise, altitude, adrenaline injection
What lowers blood volume
Posture, blood pressure
Fetal life erythropoeisis
1 2 months by yolk sac
Then by liver and spleen
Then bone marrow and lymph nodes
Post natal erythropoeisis
Bone marrow
In abnormal conditions liver and spleen
Confined to bones ( tibia ,femur,ribs, sternum, vertebrae and pelvis)
Lifespan of erythrocyte
120 days
In which stage haemoglobin isn’t produced
Mature red blood cell
True or false The number of reticulocytes in peripheral blood is more than in bone marrow
False
Vitamin b12 names
Extrinsic factor
Cyanocobalamin
Maturation factor
What b12 deficiency affects
Mylein sheath
Neutrophils
Causes megaloblastic anemia (pernicious) hb synthesis stays normal
Mcv>100 ~150
Causes of vitamin b12 deficiency
1-veganism
2- malabsorption …. gastric causes congenital lack of intrinsic factor or total or partial gastrectomy
Intestinal causes chronic tropical sprue , ileal resection
Folic acid deficiency
Megaloblastic anemia
No effect on myelin sheath
Causes of Folate deficiency
- Inadequate dietary intake
- Malabsorption: Celiac disease, jejunal resection, tropical sprue.
- Increased requirements: Pregnancy, premature infant, chronic hemolytic
anemia.
Definite effects of vitamin B12 or folate deficiency:
- Megaloblastic anemia.
- Macrocytosis of epithelial cell surface.
- Neuropathy (B12 deficiency only).
- Sterility in severe anemia.
- Rarely reversible melanin skin pigmentation.