Phto Slide 43 Flashcards

1
Q

Tropane alkaloids belongs to families?

A

Solanaceae
Discoreaceae
Erythroxylaceae
Convolvulaceae

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2
Q

How is Atropine primary formed ?

A

From hyoscymine

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3
Q

What is the m.P. of atropine?

A

118

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4
Q

Atropine is commonly obtained from?

A

Atropa belladonna

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5
Q

What is the most widely distributed alkaloid?

A

Hyoscyamine

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6
Q

What is the primary use of scopolamine?

A

Antispasmodic

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7
Q

What effect does scopolamine has on CNS?

A

Stimulate CNS

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8
Q

What is the sequence of the effect that atropine has on CNS?

A

Stimulation followed by depression or paralysis

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9
Q

Stramonium S.N?

A

Datura stramonium

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10
Q

Family of stramonium?

A

Solanaceae

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11
Q

Percentage range of alkaloids present in stramonium?

A

0.2 - 0.45%

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12
Q

% of Alkaloids found in seeds of Datura stramonium?

A

0.2%

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13
Q

Hyoscine hydrobromide used as?

A

Sedative

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14
Q

Which are used in ophthalmic practice to dilate the pupils?

A

Atropine
Hyoscine

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15
Q

Hyosciamus niger. Family?

A

Solanaceae

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16
Q

Egyptian henbane S.N?

A

Hyoscyamus muticus

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17
Q

(Egyptian hehbane) Hyoscyamus muticus belongs to the family?

A

Solanaceae

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18
Q

Principal alkaloids of hyoscamus leaf (hyoscyamus niger solanaceae)

A

Hyoscyamine and hyoscine

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19
Q

Which leaf resembles belladonna and stramonium, but weaker?

A

Hyoscyamus niger solanaceae (hyoscyamus leaf)

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20
Q

What is the principal alkaloid in hyoscamus muticus solanaceae (egyptian henbane)?

A

Hyoscyamine

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21
Q

What is the chief alkaloid of atropa belladonna solanaceae?

A

Hyoscyamine

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22
Q

% of alkaloid content range in the leaves of atropa belladonna?

A

0.3 - 0.6%

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23
Q

Mandrake S.N?

A

Mandragora officinarum solanaceae
Mandragora autumnalis solanaceae

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24
Q

Roots of madrake contains?

A

AASMH

ATROPINE
SCOPOLETIN
SCOPOLAMINE
MANDRAGORINE
HYOSCYAMINE

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25
Q

Cocaine, cinnamyl cocaine b-truxilline are derivatives of ?

A

Derivatives of ecgonine

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26
Q

Tropacocaine and valerine are derivatives of?

A

Derivatvies of pseudotropine

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27
Q

Hygrine and cuscohygrine are derivatives of?

A

Derivatives of pyrrolidine

28
Q

Tropine 2-carboxylic acid ?

A

Ecgonine

29
Q

Benzoylecgonine methyl ester respresents ecgonine or cocaine?

A

Cocaine

30
Q

Prep of cocaine
Lime or sodium carbonate —> through ?

A

Petroleum ether

31
Q

Cocaine + 5% gold chloride —> ??

A

Stellate rods

32
Q

Cocaine + platinic chloride —> ??

A

Yellow needles

33
Q

Coca leaf family?

A

Erythroxylaceae

34
Q

Brompton’s cocktail control pain of terminal cancer and is treated by cocaine HCL

A

Cocaine HCL

35
Q

Alkaloids of quinoline groups?

A

Cinchona bark
Quinine

36
Q

Cinchona bark S.N?

A

Cinchona ledgeriana rubiaceae
Cinchona succirubra rubiaceae

37
Q

Quinine is L or D
Quinidine is L or D

A

Quinine (L)
Quinidine (D)

38
Q

Cinchonine is L or D?
Cinchonidine is L or D?

A

Cinchonine (D)
Cinchonidine (L)

39
Q

Treatment of malaria?

A

Quinine

40
Q

Prophylaxis of cardiac arrhythmia + treatment of atrial fibrillation by?
+ antimalarial

A

Quinidine

41
Q

R = OCH3 is for (quinine & quinidine) or (Cinchonine & Cinchonidine)

A

(quinine & quinidine)

42
Q

R= -H is for (quinine & quinidine) or ( cinchonine & Cinchonidine)

A

(cinchonine & Cinchonidine)

43
Q

Quinine is heated with potassium hydroxide KOH in amyl alcohol producing?

A

Quinidine

44
Q

Herpathite test:
Quinine + galcial acid + %% alcohol + h2so4 —> iodosulfate of quinine

What is the percentage of alcohol?

A

90% alcohol

45
Q

Alkaloids of isoquinoline are?

BC I OH

A

Bloodroot
Curar
Ipecacuanha
Opium
Hydrastis

46
Q

Alkaloids of iso quinoline?

A

Ipecacuanha
Curar
Opium
Bloodroot
Hydrastis

47
Q

Ipecacuanha S.N?

A

Cephaelis Ipecacuanha rubiaceae

48
Q

Cephaelis ipecacuanha rubiaceae alkaloid content %?

A

2 - 2.5%

49
Q

Emetine and cephaeline are contents of?

A

Ipecacuanha ( cephaelis ipecacuanha rubiacea)

50
Q

Emetic + exceptorant + amoebic dystentery are used by?

A

Ipecacuanha

51
Q

Cephaeline methylation —> ??

A

Emetine

52
Q

What compound is Readily soluble in alcohol, ether, chloroform?

But sparingly soluble in water

A

Emetine

53
Q

What compound that is readily soluble in alcohol, chloroform
But insoluble in water.

A

Cephaeline

54
Q

Emetine and cephaeline + froehd’s reagent —>??

A

Greenish yellow

55
Q

Curare families?

Logan
Men is per mac

A

Loganiaceae
Menispermaceae

56
Q

Curare
Loganiaceae S.N?

A

Strychnos toxifera

57
Q

Curare
Menispermaceae S.N?

A

Chondodendron tomentosum

58
Q

What is used as muscle relaxant in surgical operation / neurological conditions?

A

Tubocurarine chloride

59
Q

Tubocurarine chloride + FeCl3 ferric chloride —> ?

A

Green colour

60
Q

D-tubocurarine chloride + sodium carbonate —> ??

A

Yellow brown

61
Q

?? + sodium carbonate. —> yellow browm

A

D-tubocurarine chloride

62
Q

Opium poppy S.N?

A

Papaver somniferum paparveraceae

63
Q

Opium poppy not less than %% morphine?

A

10%

64
Q

% of codeine in opium?

A

2%

65
Q

P. Somniferum var glabrum

Country? Colour?

A

Turkey

Purplish - white

66
Q

P. Somniferum var album

Country? Colour?

A

India

White

67
Q

P. Somniferum var nigrum

Country? Colour?

A

Europe

Violet