Phosphorus Flashcards

1
Q

Phosphorus food sources

A

Protein
Poultry, fish, meat
~15mg P/g Protein

Some in dairy products

Other sources:
Nuts
legumes
cereal 
grains
chocolate
Soft drinks (dark soft drinks)
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2
Q

How is Phosphrous found in food?

A

Usually not found in the free form in nature
Typically in the organic form - bound to proteins, lipids, sugars

Phytates (Phytic Acid)

  • Found in cereal grains, wheat, rice, corn
  • Beans, legumes, nuts
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3
Q

How bioavailable is Phytate?

A

Less bioavailable then Phosphorus because when consumed it will bind to other minerals such as Ca, Zn, Fe, Mg making the Phosphorus in Phytate unavailable

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4
Q

What enhances P absorption?

A

Vitamin D

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5
Q

What inhibits P absorption?

A
Phytate
Excessive intakes of:
Mg
Ca
Al
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6
Q

Food Processing does what to food?

A

Adds more phosphorus in order to preserve shelf life

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7
Q

Foods high in Phosphorus Food Additives

A
Restructured meats
Processed and spreadable cheeses
Instant products
Refrigerator bakery products
Beverages
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8
Q

Which foods would the body absorb more P from?

A

Processed foods because it is more bioavailable

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9
Q

Someone with chronic kidney disease should stay away from which foods?

A

Processed foods because the phosphorus is absorbed more.

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10
Q

How is P absorbed?

A

By facilitated diffusion

Active transport only when intake is low or demand increased

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11
Q

Active transport of P is controlled by what?

A

Vitamin D

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12
Q

What is NPT2b?

A

A transporter for P uptake into the small intestine located on the apical membrane

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13
Q

Where is P found in the body?

A

Mainly in bone
Extracellular fluid
Soft tissues like muscle

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14
Q

What are hydroxyapatite crystals?

A

Constant ratio of calcium to phosphate 2:1

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15
Q

How does phosphorus move in and out of bone mineral?

A

Ionic exchange (another ion will substitute the bone) and active bone resorption

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16
Q

P Excretion

A

Most of it is excreted in urine by kidney

Little in the feces

17
Q

What is chronic kidney disease?

A

They cannot excrete phosphorus. hence why they are on phosphorus restricted diets

18
Q

What is a major regulator of blood phosphorus?

A

Renal excretion

19
Q

Reabsorption and excretion of P vary because of

A

Blood P level

20
Q

How are phosphorus levels regulated in the blood?

A

By hormonal changes

PTH along with Calcitriol (Vitamin D) triggers release of Ca from bone along with P

21
Q

Which is more tightly regulated: Serum Ca or Serum P?

A

Serum Ca

22
Q

Serum p ranges

A

3-4.5 mg/dl

23
Q

Phosphorus Functions

A
Regualtions of acid/base balance (buffer)
DNA/RNA
Minerilization of bone and teeth
Phospholipid structure
ATP
Regulation of enzyme activity
24
Q

P Status Assessment

A

Serum P

25
Q

What is the problem with using Serum P as assessment?

A

May not reflect body P stores
Only directly related to what is absorbed
Wide diurnal variations: circadian rhythm

26
Q

P Def

A

Hypophosphatemia

27
Q

Cause of P Def

A
Low absorption
increased excretion
hyperparathyroidism
phosphorus imbalances
malabsorptive diseases
alcoholism
large doses of antacids
refeeding syndrome
28
Q

RDA

A

700mg/d

29
Q

Toxicity

A

Can cause hypocalcemia

UL 4000mg