Phenylephrine - Alpha 2 agonist Flashcards
1
Q
MOA
A
Alpha-1 receptor agonist
Cause contraction of vascular smooth muscle by upregulation of the Gq protein through the IP3 pathway which causes release of Ca+ from the SR causing contraction
2
Q
Clinical use
A
- Topically as nasal decongestant
- IV for shock
- Opthalmoscopy
3
Q
Abs/Distrb/Elim
A
Given intranasally or topically in the eye,
plasma half-life 3h
4
Q
Adverse effects
A
Hypertension
Reflex bradycardia
