Dobutamine - Beta 1 agonist

Question 1

MOA

Answer 1

Dopamine analogue. -Enantiomer is an alpha-1 agonist and a weak beta-1 agonist while the +enantiomer is an alpha-1 antagonist and a strong beta-1 agonist. It increases heart rate and contractility. The binding of alpha-1 receptors is mainly at high concentrations with vasoconstriction being the result

Question 2

Abs/Distrb/Elim

Answer 2

Short half life
Given IV
Can’t be given orally - metabolised too quickly so low bioavailability
Can’t be given chronically - due to tachphylaxis

Question 3

Clinical use

Answer 3

Short term therapeutic use of congestive heart failure and shock

Question 4

Adverse effects

Answer 4

Dysrhythmias