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med chem final > phase II > Flashcards

phase II Flashcards

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1
Q

Glucoronic Acid Conjugation

A

precedes Phase II reactions

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2
Q

What is Glucoronic acid conjugation

A

readily avalible in D-glucose

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3
Q

Enzyme for glucoronic acid conjugation

A

UDPH Dehydrogenase

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4
Q

co-enzyme that forms from glucronic acid conjugation

A

UDPGA

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5
Q

O-Glucoronidation- alcohol forms a what?

A

an ether

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6
Q

O- Glucoronidation- carboxylic acid forms what

A

an ester

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7
Q

O Glucoronidation enzyme

A

glucouronyl transferase

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8
Q

co-enzyme for O-Glucoronidation

A

UDPGA

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9
Q

N-Glucorodination- WHICH AMINES?

A

Primary and secondary amines more readily form the glucuronic acid conjugates

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10
Q

TERTIARY AMINE-N-Glucorodination?

A

NO

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11
Q

N-Glucorodination- co-enzyme

A

UDPGA

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12
Q

enzyme

A

UGT

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13
Q

S-Glucorodination: thiol to what

A

thiol to thioether

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14
Q

S-Glucorodination co-enzyme

A

UDPGA

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15
Q

S-Glucorodination enzyme

A

UGT

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16
Q

C-Glucorodination enzyme

A

UDPGA

17
Q

C-Glucorodination co-enzyme

A

glucouronyl transferase

18
Q

Sulfate Conjugation enzyme

A

sulfotransferase

19
Q

Sulfate Conjugation co-enzyme

A

PAPS

20
Q

sulfate conjugation- acts on which functional groups?

A

phenols and catechols

21
Q

Acetylation co-enzyme

A

acetyl-CoA

22
Q

Acetylation enzyme

A

acetyl transferase

23
Q

Acetylation which functional groups-?

A

primary and secondary amine, sulfonamides, and hydrazines

24
Q

Amino Acid Conjugation
functional group/ substrates

A

carboxylic acids

25
Q

Amino Acid Conjugation enzyme

A

N-acyltransferase

26
Q

Amino Acid Conjugation co-enzyme

A

the drug acts like the co-enzyme

27
Q

amino acid conjugation (where the the amino acid is the first step)

A

amino acid is the co-enzyme

28
Q

enzyme of amino acid conjugation

A

HSCOA

29
Q

methylation co-enzyme

A

SAM

30
Q

methylation enzyme

A

methyltransferase

31
Q

common substrates of methylation

A

phenols, catechols and amines

32
Q

if methylation happens on the catechol what enzyme is used

A

COMT

33
Q

if methylation happens on the amine what enzyme is used

A

N-methyl transferase

34
Q

glutathione conjugation

A

drug binds to to the thiol on the GSH and a derivative can form. this derivative is not water soluble and cannot be excreted by the body

35
Q

enzymes involved in mercaptopuric acid formation

A

γ-glutamyltranspeptidase
– Cysteinylglycinase
– N-acetylase

36
Q

4 electrophiles that can take part of mercaptopuric acid formation

A

Micheal acceptor
imidoquinone
arene oxide
epoxides

med chem final (2 decks)

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