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med chem final > Lecture 7 concepts > Flashcards

Lecture 7 concepts Flashcards

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1
Q

Microsomal Mixed Function Oxidases (MFOs)

A

enzymes responsible for hydroxylation, deamination or dealkylation

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2
Q

how are microsomes obtained?

A

obtained for in vitro testing after cell
homogenization and fractionation of ER

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3
Q

Mono-oxygenases

A

enzymes that require an NADPH or molecular oxygen

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4
Q

2 enzymes that make up MFOs

A

cytochrome p450 and NADPH Cytochrome p450 reducatase

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5
Q

CYP naming
ex: CYP3A4

A

CYP - root symbol
3 - Family is next
A- Subfamily
4- Individual gene

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6
Q

review the reduction cycle on paper

A
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7
Q

arene oxide

A

bionic

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med chem final (2 decks)

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