Phase 2 Drugs

Question 1

Overactive bladder

beta-3 agonist

Answer 1

Mirabegron

Question 2

Male LUTS

Answer 2

alpha-1 antagonists

5-alpha reductase inhibitors

Question 3

Male LUTS (+erectile dysfunction)
PDE-5 inhibitor

Answer 3

Tadalafil

Question 4

Overactive bladder

M3 antagonist

Answer 4

Oxybutynin

Question 5

Heart failure

ACE inhibitor

Answer 5

Ramapril

Question 6

Heart failure

ARB

Answer 6

Losartan

Valsartan

Question 7

Heart failure

alpha-1 + non-selective beta blocker

Answer 7

Carvedilol

Question 8

Heart failure

Aldosterone antagonists

Answer 8

Spironolactone

Eplerenone

Question 9

Heart failure

Blocks ‘funny current’

Answer 9

Ivabradine

Question 10

Heart failure

Loop diuretic

Answer 10

Furosemide

Question 11

Heart failure

Cardiac glycoside

Answer 11

Digoxin

Doesn’t increase survival and can cause DADs

Question 12

Low BP due to acute HF

beta-1 agonist

Answer 12

Dobutamine

Question 13

Severe or refractory CHF

Vasodilators

Answer 13

Hydralazine + isosorbide dinitrate combo

Question 14

Gastric ulcers

Proton pump inhibitor

Answer 14

Omeprazole

(Sulfenamide at

Question 15

Gastric ulcers

H2 inhibitors

Answer 15

Cimetidine, Ranitidine, Famotidine

Cimetidine inhibits cytochrome P-450

Question 16

Gastric ulcers

Drugs enhancing mucosal protection

Answer 16

Bismuth chelate

Sucralfate (stress ulcers eg trauma, burns)

Question 17

Gastric ulcers

Antacids

Answer 17

Na+ bicarbonate
Combine:Mg2+ carbonate
Al3+ hydroxide

Question 18

Gastric ulcers

PGE1 analogue

Answer 18

Misoprostil

Question 19

Gastric ulcers

Antibacterials for H pylori

Answer 19

Clarithromycin + amoxicillin

Question 20

Hypertension
CCB (vascular selective + non-selective)

Answer 20

Amlodipine (binds inactivated CCs)

Verapamil

Question 21

Hypertension

Alpha-1 blockers

Answer 21

Prazosin

Postural hypotension

Question 22

Hypertension (emergency)

K channel agonist

Answer 22

Minoxidil

Question 23

Hypertension

ARB

Answer 23

Losartan

Similar to ACE inhibitors but no dry cough

Question 24

Hypertension

ACE inhibitor

Answer 24

Ramipril
Dry cough
Contraindicated in bilateral renal stenosis

Question 25

Hypertension Age >55 and CCBs unsuitable Diuretic

Answer 25

Bendroflumethiazide | Hypokalaemia

Question 26

Hypertension | Beta-1 blocker

Answer 26

Atenolol | Bronchospasm, cardiac depression, fatigue

Question 27

Hypertension | Aldosterone antagonist

Answer 27

Spironolactone | Hyperkalaemia

Question 28

Angina | Beta + beta-1 blockers

Answer 28

Propranolol | Atenolol

Question 29

Angina | Inhibit funny current

Answer 29

Ivabridine

Question 30

``` Angina Nitrates (short term) ```

Answer 30

Glyceryl trinitrate | Mitochondrial ALDH-2 -> NO

Question 31

``` Angina Nitrates (long term) ```

Answer 31

GTN patches Isosorbide dinitrate (Tolerance - reactive O acts on ALDH-2)

Question 32

Angina | CCBs

Answer 32

Verapamil | Amlodipine (may cause reflex tachycardia...)

Question 33

Angina | K-ATP channel activator

Answer 33

Nicorandil

Question 34

Vasospastic angina | Relax coronary spasm using:

Answer 34

Nitrates CCBs Nicorandil

Question 35

``` Angina Statin (reduce chance of MI) ```

Answer 35

Simvastatin

Question 36

MI | COX-1 irreversible inhibitor

Answer 36

Aspirin | Reduces TXA2/PGI2

Question 37

MI | Irreversible P2Y12 antagonists

Answer 37

Clopidogrel (requires P450) | Prasugrel

Question 38

MI Reversible P2Y12 inhibitors (no need for metabolism)

Answer 38

Ticagrelor | Cangrelor

Question 39

MI | GPIIb/IIIa antagonists

Answer 39

Aabciximab