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Drugs > Phase 2 Drugs > Flashcards

Phase 2 Drugs Flashcards

1
Q

Overactive bladder

beta-3 agonist

A

Mirabegron

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2
Q

Male LUTS

A

alpha-1 antagonists

5-alpha reductase inhibitors

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3
Q 
Male LUTS (+erectile dysfunction)
PDE-5 inhibitor
A

Tadalafil

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4
Q

Overactive bladder

M3 antagonist

A

Oxybutynin

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5
Q

Heart failure

ACE inhibitor

A

Ramapril

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6
Q

Heart failure

ARB

A

Losartan

Valsartan

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7
Q

Heart failure

alpha-1 + non-selective beta blocker

A

Carvedilol

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8
Q

Heart failure

Aldosterone antagonists

A

Spironolactone

Eplerenone

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9
Q

Heart failure

Blocks ‘funny current’

A

Ivabradine

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10
Q

Heart failure

Loop diuretic

A

Furosemide

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11
Q

Heart failure

Cardiac glycoside

A

Digoxin

Doesn’t increase survival and can cause DADs

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12
Q

Low BP due to acute HF

beta-1 agonist

A

Dobutamine

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13
Q

Severe or refractory CHF

Vasodilators

A

Hydralazine + isosorbide dinitrate combo

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14
Q

Gastric ulcers

Proton pump inhibitor

A

Omeprazole

(Sulfenamide at

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15
Q

Gastric ulcers

H2 inhibitors

A

Cimetidine, Ranitidine, Famotidine

Cimetidine inhibits cytochrome P-450

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16
Q

Gastric ulcers

Drugs enhancing mucosal protection

A

Bismuth chelate

Sucralfate (stress ulcers eg trauma, burns)

17
Q

Gastric ulcers

Antacids

A

Na+ bicarbonate
Combine:Mg2+ carbonate
Al3+ hydroxide

18
Q

Gastric ulcers

PGE1 analogue

A

Misoprostil

19
Q

Gastric ulcers

Antibacterials for H pylori

A

Clarithromycin + amoxicillin

20
Q 
Hypertension
CCB (vascular selective + non-selective)
A

Amlodipine (binds inactivated CCs)

Verapamil

21
Q

Hypertension

Alpha-1 blockers

A

Prazosin

Postural hypotension

22
Q

Hypertension (emergency)

K channel agonist

A

Minoxidil

23
Q

Hypertension

ARB

A

Losartan

Similar to ACE inhibitors but no dry cough

24
Q

Hypertension

ACE inhibitor

A

Ramipril
Dry cough
Contraindicated in bilateral renal stenosis

25
Q

Hypertension
Age >55 and CCBs unsuitable
Diuretic

A

Bendroflumethiazide

Hypokalaemia

26
Q

Hypertension

Beta-1 blocker

A

Atenolol

Bronchospasm, cardiac depression, fatigue

27
Q

Hypertension

Aldosterone antagonist

A

Spironolactone

Hyperkalaemia

28
Q

Angina

Beta + beta-1 blockers

A

Propranolol

Atenolol

29
Q

Angina

Inhibit funny current

A

Ivabridine

30
Q 
Angina
Nitrates (short term)
A

Glyceryl trinitrate

Mitochondrial ALDH-2 -> NO

31
Q 
Angina
Nitrates (long term)
A

GTN patches
Isosorbide dinitrate
(Tolerance - reactive O acts on ALDH-2)

32
Q

Angina

CCBs

A

Verapamil

Amlodipine (may cause reflex tachycardia…)

33
Q

Angina

K-ATP channel activator

A

Nicorandil

34
Q

Vasospastic angina

Relax coronary spasm using:

A

Nitrates
CCBs
Nicorandil

35
Q 
Angina
Statin (reduce chance of MI)
A

Simvastatin

36
Q

MI

COX-1 irreversible inhibitor

A

Aspirin

Reduces TXA2/PGI2

37
Q

MI

Irreversible P2Y12 antagonists

A

Clopidogrel (requires P450)

Prasugrel

38
Q

MI
Reversible P2Y12 inhibitors
(no need for metabolism)

A

Ticagrelor

Cangrelor

39
Q

MI

GPIIb/IIIa antagonists

A

Aabciximab

Drugs (5 decks)

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