Pharmokinetics Flashcards
Where is thee absorption greatest for acidic drugs?
Lower pH (higher acidity)
Where is the absorption of basic drugs the greatest?
Higher pH (more basic)
Are ionized or non-ionized drugs more permeable to membranes?
Non-ionized drugs are drastically more permeable to membranes.
What size of drugs are most orally active?
Small molecule drugs
What size of drugs are least orally active?
Large molecular drugs (>1000 MW)
4 things needed for FDA drug approval?
Drug name, indication, route of administration, dose/interval
Plasma protein binding drugs
Binds to proteins so it cannot cross the membrane
What limits the drug distribution to the brain?
Blood-brain barrier
Where in the body will small water-soluble molecules stay?
Total body water
Where in the body will larger water-soluble molecules stay?
Extracellular water
Where in the body will large protein molecules stay?
Plasma
Where in the body will highly lipid-soluble molecules stay?
Fat
If volume of distribution in higher that possible, what does that indicate?
Concentration is greater in the peripheral tissues than in the blood
Ion trapping
Acidic drugs accumulate on the more basic side.
Basic drugs accumulate on the more acidic side.
What characteristics of the brain capillaries form the BBB?
Tight cell junctions and astrocytic sheath
