Pharmocology Flashcards
1
Q
Increased theophylline level effects
A
Incr cAMP -> arrhythmias
2
Q
Drug induced lupus
A
- Slow acetylators
- N-acetyltransferase
- hydralazine, procainamide, isoniazid
3
Q
Acetominophen metabolism by what Phase II process
A
Glucuronidation
4
Q
Deficiency in UGT1A1
A
- Gilbert or Crigler-Najjar
- incr unconj bilirubin levels
- bilirubin cleared by glucuronidation
- enzyme = glucuronosyltransferase
5
Q
Effects of statins and P450 inhibs (grapefruit juice)
A
Incr risk of muscle pain
6
Q
Acidification of urine
A
- Increases ionization of weak bases -> increases renal elimination
- use for OD of amphetamines, PCP
- put drug in protonated form to stay in urine
7
Q
Alkalinzation of urine (use NaHCO3)
A
- Increases ionization of weak acids -> inceases renal elimination
- OD of aspirin
8
Q
Acids
A
Aspirin, loops, thiazides
9
Q
Bases
A
Local anesthetics, amphetamines, PCP
10
Q
Ionized
A
Water soluble
11
Q
Nonionized
A
Lipid soluble
12
Q
LD equation
A
LD = Vd x Cp
13
Q
MD equation
A
MD = Cl x Css
14
Q
Gs protein receptors
A
- Gs proteins increase cAMP production
- Gs = all B (B1, B2) , D1, H2, V2
15
Q
Gi protein receptors
A
- decr cAMP production
- MAD2 = a2, M2, D2
