Pharmocology Flashcards
pt exposed OR infected but does not have serious disease
Prophylactic therapy
Pt infected but not sick yet
Preemptive therapy
Pt symptomatic but organism is unknown and you treat anyway
Empiric therapy
organism is known and Abx chosen accordingly
Definitive therapy
antimicrobial coverage at low dose when infection has not been completely eradicated
Post-treatment suppressive therapy (ex bacterial colony on prosthesis)
what drug would you use to tx streptococci? What is its class and mechanism of action?
Penicillin G
penicillin
inhibits transpeptidation; binds PBP prevents PG cross linking; leads to cell autolysis
what drug would you use to tx staphylococci? What is its class and mechanism of action?
nafacillin
penicillin
inhibits transpeptidation; binds PBP prevents PG cross linking; leads to cell autolysis
what drug would you use to tx enterococci What is its class and mechanism of action?
ampicillin
penicillin
inhibits transpeptidation; binds PBP prevents PG cross linking; leads to cell autolysis
what drug would you use to tx pseudomonas What is its class and mechanism of action?
piperacillin
penicillin
inhibits transpeptidation; binds PBP prevents PG cross linking; leads to cell autolysis
What does HELPS kill enterocci stand for?
What drug is used for this?
H. influenza, E. coli, listeria, P. mirabilis, enteroccis
Ampicillin, amoxicillin
MOA of beta lactamase inhibitors
prevent destruction of beta lactam antbiotics
Which group is fluoroquinilones contraindicated in and why?
Children; Achilles tendon rupture
What drug causes Achilles tendon rupture?
Fluoroquinilones
which drug covers Rickettsia?
MOA?
Doxycycline
binds 30s Ribsomal subunit
Which drug covers borrelia burgdorferi? what disease
Lyme’s disease; Doxycycline
