Pharmcodynamics

Question 1

2

Describe the relationship between drug conc. and receptor bound receptors in the dose response curve?

Answer 1

It is not linear, plateus at a given concentration

Question 2

2

What is a dissociation constant (kd)?

Answer 2

The conc. of drug at which 50% of receptors are occupied

Question 3

What does a left-shifted dose response curve indicate?

Answer 3

Higher affinity of the drug

Question 4

What is the Hill langmuir equation and what does it measure?

Answer 4

It tells you now much receptor is occupied at a given drug concentration

Question 5

Define drug efficacy?

Answer 5

defined by whether drug can produce a 100% therapeutic effect

Question 6

Define Potency?

Answer 6

measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.

Question 7

Why is it possible to get 100% efficacy without having 100% receptor occupancy?

Answer 7

signal amplification- just one molecule can prompt a cascade

Question 8

What is receptor reserve?

Answer 8

receptors that are available for agonist binding but are not necessary for max effect

Question 9

What effect do competitive antagonists have on agonist?

Answer 9

Potency of the agonist

Question 10

What effect do non competitive antagonist have agonists?

Answer 10

They decrease efficacy of the agonists