Pharmacy And Prescribing Flashcards
1
Q
What is polypharmacy?
A
Use of multiple medications by a patient
Prescribing 4+ to the same person
2
Q
What are the pharmokinetic changes to drugs in the elderly?
A
Impaired first pass metabolism (↑ bioavailability)
Reduced renal clearance (accumulation, adverse events)
Impaired hepatic clearance (accumulation, adverse events)
3
Q
What are the pharmodynamic changes to drugs in the elderly?
A
Age related reduction in receptor sites
Reduced homeostatic reserve (↑ sensitivity to drugs affecting postural control, cognitive function, visceral muscle function)
4
Q
What is the number of individuals required to receive a new experimental drug as a safety test?
A
50
