Neurodegenerative

Question 1

What are the clinical features of Parkinson’s disease?

Answer 1

Tremor
Rigidity
Bradykinesia
Postural instability

Question 2

What are the non-motor manifestations of Parkinson’s?

Answer 2

Mood and cognitive changes
Pain
Urinary symptoms
Sleep disorder
Sweating

Question 3

What are the pathological features of idiopathic Parkinson’s disease?

Answer 3

Neurodegeneration
Leah bodies (synucleinopathy)
Loss of pigment
Reduced dopamine

Question 4

What are the effects of IDP on the basal ganglia circuit?

Answer 4

Loss of dopaminergic neurones in substantia Nigra
Reduced inhibition in neostriatum
Increased production of ACh (excitatory)
Chain of abnormal signalling leads to impaired mobility