Pharmacy Flashcards
Acidic drugs require an acidic environment to be absorbed, and basic drugs require a basic environment to be absorbed. True/False?
True
Give 3 examples of acidic drugs
Penicillin
Aspirin
Phenytoin
Give 3 examples of basic drugs
Diazepam
Morphine
Pethidine
What will the absorption of penicillin be like if you take a PPI at the same time?
PPI remove HCl from stomach, so less acidic environment, so penicillin won’t absorb as well
Which carrier protein binds acidic drugs?
Albumin
Which carrier protein binds basic drugs?
Alpha-1 acid glycoprotein (A1AG)
In the elderly, which carrier protein is higher in abundance - albumin or A1AG?
A1AG
Relative low albumin concn
Vd is a theoretical volume describing if all drug was absorbed into blood. The bigger the Vd, the more/less lipid soluble it is.
Vd is a theoretical volume describing if all drug was absorbed into blood. The bigger the Vd, the more lipid soluble it is.
What effect does a large Vd have on half-life of a drug?
Half-life of drug increases (big Vd means drug is sitting in adipose tissue)
Give the equation for calculating the therapeutic index of a drug
LD50/ED50
lethal dose50)/(effective dose50
List some drugs that have a narrow therapeutic index
Warfarin Theophylline Levothyroxine Digoxin Lithium Vancomycin Gentamicin