Pharmacotherapy of ED and BPH Flashcards
What is first line therapy for ED?
PDE 5 Inhibitor
What is second line therapy for ED?
Intracavernosal injections of erectogenic drugs OR intraurethral prostaglandin suppository
What is adjunct therapy for ED?
TST ONLY for patients with LOW levels
What is the function of PDE5i?
Selectively inhibits PDE5, enzyme that inactivates cGMP
If a patient fails 1 PDE5i what is the next step?
Try another PDE5i within the class before considering the entire class as treatment failure
Sildenafil Brand Name and Initial Dose?
Viagra, 50 mg 30 min-4hrs before intercourse
What is the renal and hepatic dosing for >65 for Viagra?
25 mg initially
What can cause delay absorption fo Viagra and Levitra?
High Fat Foods delaying absorption by 1 hr
Vardenafil Option 1 Brand Name and Initial Dose?
Levitra, 5-10 mg 1hr
What is the renal dosing for >65 for Levitra?
5 mg initially
caution in hepatic
Vardenafil Option 2 Brand Name and Initial Dose?
Staxyn, 10 mg 1hr
What is the renal dosing for Staxyn?
No renal dosing
CI in hepatic
What is the counseling pearl for Staxyn?
Take without food/liquid
Dissolve tablet on tongue
Tadalafil Brand Name and Initial Dose?
Cilalis,
10 mg 30 min-36 hr OR
2.5 mg daily
What is the renal dosing for Cialis?
No renal dosing
CI in hepatic
What PDE5i has cautionary use with alpha blockers?
Cialis and Stendra
Avanafil Brand Name and Initial Dose?
Stendra, 100 mg 15-30 min
What is the renal dosing for Stendra?
AVOID in CrCl ,30 and hepatic
What is CI with Stendra?
CYP3A4i, avoid large amounts of ethanol = orthostatic hypotension
What is onset for Viagra and Levitra?
30 mins
What is onset for Staxyn?
60 mins
What is onset for Cialis?
45 mins
What is onset for Stendra?
25-40 mins
What is the duration of Cialis?
24-36 hrs
What are side effects most common in Vardenafil?
HA, Flushing, and Blue Vision
Blue Vision is a side effect seen with which PDE5i?
Sildenafil, Vardenafil, and Avanafil
What is a common side effect of Tadalafil?
Myalgia and Back Pain
When are PDE5i Contraindicated?
In patients taking Nitrates
Isosorbide Mono/Di-nitrate or SL NTG
What is the result of PDE5i + Nitrate?
Life threatening HYPOtension
If the patient is already on a nitrate, can you prescribe PDE5i?
NO
If the patient is on a PDE5i, can you administer nitrates?
Yes IF they have waited the appropriate amount of time
How long do you have to wait for Sildenafil before nitrate admin?
24 hrs
How long do you have to wait for Vardenafil before nitrate admin?
24 hrs
How long do you have to wait for Tadalafil before nitrate admin?
48 hrs
If the patient is already on an alpha-blocker (some interaction) what dose of PDE5i do you start the on?
Lowest
What are the advantages of PDE5i?
Convenient, low A/E, all equally effective, and discreet use
What drug is a Prostaglandin E1?
Alprostadil
What is the MOA and Place in therapy for Alprostadil?
Dilates arteries in the corpora cavernosa which thus increases penile blood flow, 2nd line
Can Alprostadil be used with TST?
Yes
Alprostadil Option 1 Brand and Initial Dose?
Caverject, Edex
2.5 mcg intraCAVERNOSALLY 5-10 min
When do you AVOID Alprostadil?
Sickle cell anemia, coagulopathy, venous incompetence, and Peyronie’s disease
Alprostadil Option 2 Brand and Initial Dose?
MUSE
125-250 mcg intraURETHRALLY 5-10 min
What are the AEs of Intracavernosal Caverject/Edex?
Penile Pain
Hematoma
Fibrotic nodules
What are the AEs of Intraurethral MUSE?
Urethral pain/burning
Partner experiences burning
Testicular pain