Pharmacometrics/TDM Flashcards
1
Q
Importance of pharmacometrics
A
- Safety analysis
- Efficacy analysis
- Individualised dosage specimen
- Rational drug treatment
- Drug response predictability
- Drug development
2
Q
Pharmacometrics models
A
- PK
- PD
- PK-PD, aka exposure-response
- Physiologically-based PK
- Disease progression model
- Trial model
3
Q
Steady state plasma concentration
A
This is the point at which a repeatedly administered drug that accumulates in the body has a rate of elimination that equals the dosing rate or the amount administered per time.
4
Q
Loading dose
A
A single or few quickly administered doses given in the beginning to attain target conc rapidly.
5
Q
Maintenance dose
A
Repeatedly administered dose given at specific intervals after attaining target steady state to maintain same by balancing elimination.
6
Q
Drugs administered with loading and maintenance dose
A
Digoxin
Chloroquine
Amiodarone
7
Q
Drugs commonly monitored with TDM
A
Digoxin
Phenytoin
Carbamazepine
Gentamicin
Phenobarbital
Cyclosporine
Propranolol
