Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

MRCP > Pharmacology/Toxicology > Flashcards

Pharmacology/Toxicology Flashcards

1
Q

Drug induced thrombocytopenia

A

Quinine

Abciximab

NSAIDs

Furosemide

Abx - penicilins, sulphonamides,
rifampicin

Anticonvulsants - Carbamazepine, Valproate

Heparin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Carbon monoxide affect on O2

A

Causes decreased O2 saturation of Hb - - > LEADS TO EARLY PLATEAU

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Ciclosporin side effects

A

EVERYTHING INCREASED:

BP
Gums
Hair
K+
Fluid
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Pharmacokinetic terms :

Half life

Volume of distribution

A

Half life = time taken for plasma drug conc to decrease by half

Volume of distribution - calue that descibes the extent at which a drug is retained within circulation or distributed elsewhere.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Pharmacodynamic termsL:

Efficacy

Emax

Potency

A

a measure of drug effects in a particular symptom

Emax - maximal effect - partial agonist Emax < Full agonist

Potency: Expresses drug efficacy in relation to dose/conc.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Pharmacokinetics - Metabolism

A

2 types of biochemical rxn:

Phase 1:

  • oxidation/reduction/hydrolysis.
  • P450
  • toxic/reactive product

Phase 2:

  • Conjugation
  • products less reactive
  • typical groups - glucoronyl/acetyl/methyl/sulphate

1st pass metabolism:
- Drug is extensively etaboliused before reaching systemic circulation.
in LIVER
- ASA, verapamil, GTN, Propanolo, ISMN, hydrocortisone, testosterone

Zero-order kinetics:

  • Metabolism is independent of drug conc.
  • Metaboplic pathway= saturated
  • Phenytoin, ASA, Heparin, Ethanol
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Drug induced lupus

A

Assoc with Acetylation and HLA-DR4

Ft:

  • butterfly rash
  • myalgia
  • pleurisy

Causes:

  • PROCAINAMIDE
  • HYDRALAZINE
  • others: isoniazid, phenytoin, minocyclione

Inx:

  • ANA +,/ dsDNA -
  • anti-histone Ab
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Liver inducers/inhibitors

A

inducers - stop warfarin - PCBRAS
- Pghenytoin/carbamezapine/barbituates/rifampicin/alcohol/St Johns wort

Inhibitors - inc warf - AODEVICES
- allopurinol/omeprazole/disulifram./erythromycin/valproate/isoniazid/ciproflox/ethanol/sulfonamide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Fx of COCP

A

decreased absopriton - e.g. diarrhoea

Liver inducers

Con-comitant broad-spec Abx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

drugs to avoid in pregnancy

A

Earyl - teratogenics:

  • Li - cardiac abnormalities
  • ACEI/ARBs - oligohydraminos
  • phenytoin - cleft lip/palate
  • Na Valp - NT Defects/spina bifida
  • Warfarin

Late preg –> X placents:

  • Carbimazole –> neonatal goitre
  • Gentamycin - CN8 deafness
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

prescribing in BReastfeeding

A
  • Amiuodarone
  • n Cytotoxics
  • Gold
  • Indometacin
  • Li
  • Iodides
  • OEstrogens
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Liver Fx

A

Increase susceptible to sedatives/ drugs taht cause encephalopathy

Thiazide/loop diuretics –> hypokalaemia –> Encephalopathy

Rifampicin - accumulates as excreted in bile
Hypoalbuminaemia –> Phenytoin toxicirty
Poor clotting –> Warfarin leads to bleed
NSAIDs - Inc NA/H2O retention

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Cardiology drugs

A

Abciximab - glycoprotein 3a/2b inhibitor –| platelet aggregation

Adenosine - activates K+ in SAN/AVN - CI - Asthma

Aliskiren - Direct renin inhibitor - used in essential HTN
- S.e High K+

Amiodarone:
- prolongs refractory period
- long half life
- give IV - effect hrs
- PO effect = weeks
- it is the LEAST NEG INOTROPIC ANTIARRHYTHMIC
\s.e. - CHIPCHANGE - cutaneous photosensitivity/hep dysfn/inc LDL/pulm fibrosis/CNS/hypo/hyper-thyrid/asx corneal deposits/neuropathy/GI effect/ Enhanced warf and dig

ACEI:

  • CI - BL RAS
  • S.e. - dry cough/hyperkalaemia/hypersesnsitivity

Clopidogrel:

  • Inhibits ADP bindiong site on platelet - stopp aggregation
  • P2Y12
  • longer anti-plt than ASA –> bleeding risk for 7/7

Digoxin:

  • Slows AVN conduction –> Blsacks Na/K+ ATPasa pumo
  • eliminated by KIDNEYS
  • S.e. –> Gynaecomastia

Flecainide:

  • class 1c anti-arrythmic
  • avoid if IHD/structural heart dx

Statins:

  • HMG CoA reductase inhib –> inhib RLS of cholesterol synth
  • S.E. - myopathy/drug induced hepatitis

Ivabradine_

  • Funny current blocker - inward NA-K channel - found in SAN
  • S.e - visual effects, headache, bradycardia/HB

Nicorandil:

  • V.D. used in angina
  • activates K+ Channels –> inc. cGMP
  • S.E. - headache, flushing, ulceration
  • CI - LVF

Pasugrel/Tocagrelor:

  • P2Y12 receptor inhibitor
  • use Ticagrelor in ANY NSTEMI
    s. e. - bleeding/ brady + inc SOB (ticagrelor)

Thiazide:

  • hypo Na/K/Mg
  • hypochloraemic acidossis
  • postural hypotension
  • agranulocytosis
  • pancreatitis
  • thrombocytopenia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Digoxin toxicity

A
  • reverse tick
  • arrythmias
  • confusion
  • yellow-green vision

precipitants:

  • hypokalaemia - competively competes with dig
  • low MG / High Ca
  • Inc Age/ RFx/
  • MI
  • Drugs 0- amiodarone/verapamil/ dilitiazerm

Mx:
[- Digi-bind
- correct arrythmioa
- Monitor K+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Endocrinology - Drugs

A

Carbimazole:

  • inhibits peroxidase enzyme
  • Agranulocytosis
  • X placenta –> neonatal goitre/hypothyrpoid.

HRT:

  • reduces bone fracture
  • inc breast Ca

NAteglinide/repaglinide:

  • INCREASE INSULIN secretion
  • similar mechanism as SU
  • good for postprandial hyperBGL as short 1/2 line
  • S.e> - GI Upset/hypersensitivity rxn
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

GAstro - drugs

A

S-ulfasalazine:
- S- afe in oregnancy ]- pro -drug of 5-ASA –> dec neutrophil chemotaxis/lymphocyte prolif/pro inflamm cytokines.
- cuation w/ G6PD deficiency or allergy to aspirin/sulkphonamides.
S.e. - oligospermia/SJS/ pneumonitis/lung fibrosis. myelosupression/heinz body anaemia/ coloured tears

Mesalazine/Osalazine:

  • types of 5-ASA
  • S>E - GI Distrubance / headache/pancretitis

Orlistat:

  • Inhibits pancreatic lipase
  • used ij obesity if BMI >30 or BMI > 28 + RF or cont WL
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

PArkinsons meds - See neuro notes

A

MAO-B inhib - Selegline

Amantadine - inhibit reuptake of DA

L-DOPA

  • absorbed in prox. small bowel - decr. if AA present
  • prodrug
  • netabolised by COMT
  • S.e. - Arrythmia/dyskinesia/post lowBP /psychosis/somnolescence

DA-R agonisst:

  • Carbegoline/bromocriptine/apomorphine/ropinerole - less dyskinesia vs L-DOPA
  • inc neuro psych s.e. ]
  • pulm/retroperitoneal fibrosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Epilepsy meds

A

lamotrigine

  • inhibits glutamate
  • s.e. mood change/mavulopapular rash/influenza symptoms/SJS

Gabapentin:
- GABA isomer

Leviteracetam
- presynaptic GABA release

Vigabatrin
- irreversible inhib of GABA transaminase –> inc GABA activity

BZD:
- inc affinity for GABA to bind to it’s receptor

Carbamezapine:

  • derivative of TCA:
  • HEadache/diplopia soon after starting ]
  • morbilliform rash
  • toxic epidermal necrolysis
  • AGRANULOCYTOSIS

Valproate - S.e = V.A.L.P.R.O.A.T.E

  • Vomitting/allopecia/liver toxicity/pancytopaenia or pulm fibrosis/ retention of fat = wG/ pedema/ataxia/ teratogenic or tremor/ enzyme inhib.
  • AGRANULOCYTOSIS

5 HT - agonist:
- Triptans
- used in acute migraine
0- do not give in 24 hr of hemiplegic migraine or egotamine –> Vasospasm
- S.e. - chest paibn, flushing, drowsiness, vasospasm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Rheumatology drugs

A

MTX:

  • Folate agonist - inhibits dihydrofolate mediators
  • 1st kline in RA
  • S.e. - Pulm fibrosis /mucositis/myelosupression.pneumonitis/liver fibrosis
  • m Preg - avoid for 6/12
  • monitor FBC/U+E/LFT - @ start –> wkly until stable –> every 2-3/12
  • interactions - Trimethoprim/co-trimoxazole –> marrow supressionm
  • ionteractions - high dose ASA –> inc toxicity
  • MX toxicity with folic acid

Allopurinol:

  • Inhibits xanthine oxidase –> stops purne synth
  • inc risk of acute attach on commencent
  • can cause accum of azathiprine
  • decrease clearance of cyclophosphamide

Colchicine:

  • Inhibits macrophage migration
  • s.e. –> diarrhoea

Febuxostat:
- Xanthine oxidase inhibitor.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

TOXICITY BEAR

A

LOOK UP PIC

Azathiprine - neurotoxic 
Cisplatoin - ototoxic and nephrotoxic 
Doxyrubicin - Cardiotoxic 
PSI - cyclophosphamide - bladdeer toxic 
 MTX - Nephrotoxic/myelosupression 
Vincristine - periph neuropathy 
Vincristine 0- periph neuropathy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Retinoids

A

usewd in sev psoriasis/acne

Teratogenic --> NT Defect 
0
S.e.: - Benign IHH
- dry mucus memrban e
- PHOTOSENSITIVITY 
- decreased night vision
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Strontium

A

used in post-menopauesal osteoperosis

S.e.:
- Sev Allergy
DRESS - drug rash w/ eosinophillia and systemic sx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Spec drug adverse effects

A

Amennorhgea:

  • DA block - chlorpromazine, cimetidine
  • Na Valproate

Bronchospasm

  • ASA
  • BSAIDs
  • Adenosine
  • beta blkocker

Dyskineasia:
- L- DOPA > other antiparkinsons

Gynaecomastia:

  • OEstrogen like - Dig/ spiro
  • anti-androgen –> LHRH analogue/cimetidine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Drug induced liver dx

A

Heoatocellular:

  • Paracetamol
  • Valproate
  • MAOI
  • Halothane
  • anti-TB - R.I.P
  • statins
  • Alcohol/amiodarone
Cholestasis:
- COCP
- Fluclox / erythomycin / co-amox 
- anabolic . steroids
- chlorpromazine/promethazine
-

Liver Cirrhosis

  • MTX
  • amiodarone
  • methyldopa
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

drug provoked myasthenia

A 
amenoglycloside
beta block 
phenytoin 
penicillamine 
procaiamide 
lidocaine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

drug induced photosensitivity

A 
Amiodarione 
Tetracyclines 
RETINNOIDS 
PSoralen 
Cipro
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

drug induced vasculiuti s

A 
allopurinol 
\Catopril 
Cimetidine 
LTRA 
penicillin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

acute pancreatitis - drug causes

A 
antiretrovirals 
azathiprine 
corticosteroidn 
fibrates 
statins 
thiazides
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

SIADH - derug causaes

A

Carbamazepine
chlorpropamide
cytotoxic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

PAracetamol OD

A

liver normally conjugats paractamol + glutathione

in OD –> saturated –> all glutatjione used. Therefore get oxidation of P450 mixed fn oxidases. –> toxic metabolite = N- Acetly - B - Benziquinoneimine.

Mx:

  • <1hr –> aCharcoal
  • > 1hr/staggered –> NAC
  • at 4hrs if level >100 –> NAC
  • @15hrs >15 –> NAC

S.e of NAC:
- Anaphylactoid rxn –> STOP and restart @ SLOWER rate.

Kings college criteria:
- Arterial pH <7.3

or All of :

  • Cr >300
  • PT <100
  • Encephalopath grade 3/4
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

TCA OD

A

Amitriptyline + dosulepin

Early sx:

  • dry mouth
  • blurred vision
  • sinus tachy
  • agitation
  • blurred pupil

Ft of sev poisoning:

  • Arrythmias
  • Seizures
  • Metabolic acidosis
  • Coma

ECG Changes:

  • Tachy
  • Wide QRS - >100 - seizures >140 –> VT
  • prolonged QT

Mx:

  • IV NaHCO3-
  • IV lipid emulsion
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Throphylline toxicity

A

Sev acidosis
Tachy
Hypokalaemia
LOC/seizures/confusion

MX:

  • Rpt aCharcoal
  • IVI
  • Electrolyte
  • if level >60 !!! –> HAEMODYALISis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

CO Poisoning

A

PX - >1 person from samew hosue px with flu-like sypmpotoms –> then get:

  • pounding headache
  • cherry red skin
  • N.V
  • Fatigue
  • FALSELY HIGH PO2

CO + Hb –> Carboxyhaemoglobin = MEASURE

Carboxy-Hb ;evels:

  • <3% normal
  • 3-10% = smokers
  • 10-30% = symptoms
  • > 30% = severe

Mx:

  • 100% O2
  • Hyperbaric O2

indications for hyper baric OR:

  • LOC
  • neuro signs
  • MI/arrythmia
  • Pregnancy
34
Q

Quinine toxicity

A

Anticholinergic + Direct neurotoxic –> BLINDNESS

prolonged QT

alpha blocjk –> HGYPOTENSION
TINNITUS
SEV METAB ACIDOSIS

35
Q

Pb Poisoning

A

Think if ABDO PAIN + NEURO SIGNS

also get blue lines on lid margin

Inx:

  • Blood Pb >10
  • microcytic anaemia

Mx = chelating agent:

  • DMSA
  • D-penicillamine
  • EDTA
36
Q

Ecstasy poisoning

A 
Agitation 
]sweating ]tachy
dilated pupils
htn 
hypoNa
hgih temp 
rhabdomyolysis

Tx:

  • supportive
  • if Temp very high depsirt supportive –> Dantrolene
37
Q

Mercury poisoning

A 
blindness 
hearing loss
parasthesia 
RTA 
irritabilty
38
Q

cyanide poisoning

A

inhibits Cytochrome C ocidase –> inhibits mitochondrial e- chain

Brick red skin + smell of bitter almonds

Mx:

  • 100% O2
  • HYDROXOCABALOMIN
39
Q

Methanol poisoning

A

DRUNK + VISUAL problems

Mx:

  • Fomepizole or ethanol
  • Haemodialysis
40
Q

insecticide poisoning

A

Inhibits scetylcholinesterase –> inc cholinergic side. effects

Ft - SLUD

  • salivation
  • lacrimation
  • urination
  • diarrhoea

Mx
- Atropine

41
Q

Ethylene glycol toxicity

A

USed coolant/antifreeze

Ft of toxicirty:

  • stage 1 - like being drunk
  • 2 - metab H+ with inc anion gap
  • 3 - ac ute renal fx

Mx:

1) Fomepizole
2) Ethanol/HD

42
Q

Drug causes of photosensitivity

A 
Thiazides
Tetracycline, cipro, sukphonamides
Amiodsrone
Nsaids
Psoralen
Sulphonylureas
43
Q

Which drugs are assoc wuth acetylator status

A 
Procainamide 
Hydralazine 
isoniazid 
sulfasalazine 
dapsone
44
Q

Drugs that exhibit Zero Order Kinetics

A

Phenytoin
Salicylates
Heparin
Ethanol

45
Q

Kings collecge criteria for liver transplant in paracetamol OD

A

At 24 hours:

pH <7.3

or all of:

PTT >100 secs
Cr >300

Grade 3 or 4 encephalopathy

46
Q

Causes of raised anion gap acidosis:

CAT MUDPILES

A

C - Cyanide/ CO

A - aminglyclosides

T- theophylline/toluene (glue)

M - MEthanol

U - Uraemia

D - DKA/ starvation KA/ Alcoholic KA

P - paracetamol/acetoaminophen

I - Isoniazid/inborn error of metab/ IRon

L - LActic acidosis

E - Ethanol/ethyene glycol

S - Salicylates/ASA/Aspirin

47
Q

Drugs that cause photosensitvity:

SAT

A

Sulphonamides

Amiodarione

Tetracycline

48
Q

Adrenoreceptor anatg

A

Apha - 1 = Doxazosin
Alpha - 1a = Tamsulosin
Alpha (non-selective) = phenoxybenzamine

beta - 1 = Atenolol (A for 1)
non-selective beta = propanolol

49
Q

Drug induced impaired glucose tolerance

A 
Thiazides/
Steroids
tacrolimus/ciclopsotin 
IFN-alpha 
nicotinic acd 
antipsych
50
Q

Contraindications to COCP

A 
Migraine with Aura 
>35 and smoking >15/day 
BP persitent >160/95
maj surgery 
secondary raynauds 
SLE w/ Anti-phospholipid
BReast Ca 
<6/12 Post-partum and breastfeeding.
51
Q

When to check phenytoin levels after a dose change

A

2 Weeks.

Half life of phenytoin = 22 hours. Can take 5 - 14 days to reach a steady state.

10 - 20 = range for therapeutic

52
Q

SIADH Drug causes:

SIADH Causes Poor Voiding

A

ssri/indomethacin/antidepressants (TCA)/diuretics - furos/bendro

C CARBEMAZAPINE/cyclophosphamide/chlorpromazine

P - phenothiazine

V- Vincristine/vinblastin

53
Q

Pseudomembranous collitis

A

Cephlasporin >clinda >cipro

54
Q

Drugs and Vision

1) Blue
2) Colour viision
3) haloes + Photosensitivity
4) Yelolow
5) Red/green affected

A

1) Viagra - blue pill
2) Chloroquine
3) Amiodarone
4) Dig
5) Isoniazid

55
Q

Olyguric Crisis - causes and management

A 
Neuroleptics - onlanzapine + haloperidol 
Metoclop 
Domperidone 
Carbamexapine
chlrooquine

Mx:
- IV Procyclidine
others = benzhexol/benzadyle

56
Q

Anti- HTN in preg

A

Methyldopa/labetolol/hyrdalazine

late pref –> Nifedipine

57
Q

Acquired AIHA

A

methyldopa
penicillin
quinine
quinidine

58
Q

Highly protein boudn drrugs

A

ASA/warf/phenytoin/digitoxin/valroate/nifedipine/propanolol/verapamil

Increased action in low alb states —> unbound drug leads to action

59
Q

why do you get nitrate tolerance with GTN use?

A

formation of reaction oxygen species

60
Q

Theophylline toxicity

A

Ft:

  • Tachy/seizures/metabolic acidosis
  • Tremor
  • Vomit
  • Insomnia

Mx:

  • acute tachy –> Esmolol
  • If arrythmia –< HAEMODYALISIS
61
Q

Amitryptilline OD

A

Cant see pee spit or shit
Acidosis
Prolonged QT

Mx:
mild –> IVI
Sev –> IV NaHCO3

62
Q

Fruit + Drug interation

A

Inhibitors - Grapefruit + Seville orange –> Simvastatin/amlodipine/diazepam/nifedipine

Inducers: Cranberry juice
- doesnt affect statisn

63
Q

Drug induced oedema

A

intermittent facial oedema = moxonidine

PEripheral oedema = amlodipine

Angioneurotic oedema - ace-I

64
Q

drug induced prolonged QT

A

Sotalol/quinidine/procainamide/amiodarone

Antipsych/domperidone/clarithromycin/erythromycin/cipro/trimethoprim/domperidone/cocaine

65
Q

Hyper-PRL drugs

A

DA Antag - Phenothiazones/risperidone/metoclop

DA Depleting - MEthyldopa/isoniazid/TCA/ Verapamil/Oestrogens

66
Q

Antiaeeythmics

A

Type 1 - Na channel (Double Quarter pounder/ with Lettuce Mayo and Tomato/ and More Fries Please
1a = quinidine/procainamie/disopyramdie
1b = lidocaine.moxeletine/tocainide
1c=flecainids/propefenanone

Type 2 - betablocker (Lol)

Type 3 - K+ blocker (this is SAD)

  • Sotalol
  • Amiodarone
  • dofelitide

Type 4 - Ca-channel blocker ( I and V in IV)

  • d-i-lt-i-azem
  • V-erapamil
67
Q

Drug precipitant of psoriasis

“NAAL man i don want psoriaisis

A

Nsaids/Atenolol/antimalarials/Li

68
Q

BZD overdones

A

Managemengt - SUPPORTIVE +/- flumazenil (inc seizure risk)

69
Q

Digoxin OD

A

Downlslope ST, Short QT and prolonged PR, U wave

Mx:
- HD unstable –> DC cardioverion
Otherwise DIGIBIND

Monitor K+ and renal fn

70
Q

Warafrin in pregnancy

A

Stop in 1st 2/52 of preg and cover with lmwhh –> restart at 2/52 –> 3rd trimester stop and cover LMWH–> Start 2/52 psot=partum

71
Q

Black triangle in BNF meaning

A

Recently added therefore must report advers affects = yellow card scheme

72
Q

MEthanol poisoonig

A

Ft –> BLINDNESS

Mx = Ethanol/fumepazole

73
Q

Drug cause of dupyterns contracture

A

PHENYTOIN

74
Q

Chloroquine toxicity

A

NAusea, headache, visual disturbance, arrythmia coma
Hypoglycarmia
interferes with cardiac NA channels –> PROLONGED QRS

75
Q

MTX Interatcion

A

Trimethoprim and co-trimoxazole–> myelo supressopm

Checl U+Es weekly –> sstable then every 2-3/12

76
Q

Monoclonal Ab

A 
Inrfliximab - anti-TNFa - RA/Crohns/CML
Rituximab - CD20 - NHL/RA
Cetuximab - EGFR - met colorectal ca/ Head + neck Ca 
Transtuzumab - HER2 - met breast
Alemtuzumab - CD52 - CLL
77
Q

Drug monitoring

A

Li - 12 hr post dose
Dig - 6hr post dose
Ciclosporin - immed b4 next dose

Phenytoin:
- doesnt req reg monitor 
only if:
?toxicity 
?compliance
Dose change 
- Immed before next dose
78
Q

Drugs that precipitate AIP

A 
BArbituates 
BZD
Halothanes
EtOH
OCP
Sulphonamides
79
Q

Heparin vs LMWH MOA

A

LMWH:
- Activates antithrombin 3 –> FXa inhibition

Heparin
- Activates antithrombin 3 –> inhibits F9,10,11,12

80
Q

Indications for NA Bicarb in TCA OD

A

Reduced consciousness
QRS>100
Metabollic acidosis

MRCP (20 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions