Pharmacology Test 4

Question 1

enzymes that end in “-ase”

Answer 1

thrombolytics

Question 2

warfarin has a _______ therapeutic range

Answer 2

narrow

Question 3

high INR yields _________ risk of bleeding

Answer 3

increased

Question 4

low INR yields increased risk of ___________

Answer 4

thromboembolism

Question 5

antithrombotic uses for warfarin include…?

Answer 5

AF, prosthetic valves, DVT/PE prophylaxis

Question 6

It’s presence leads to decreased dose of warfarin d/t decreased P450 activity

Answer 6

CYP2C92 and CYP2C93

Question 7

warfarin dosing guidelines

Answer 7

start low, go slow

Question 8

DMARD of first choice to treat RA is …?

Answer 8

methotrexate

Question 9

nor-epi, serotonin, dopamine

Answer 9

biologic amines

Question 10

decreased levels of nor-epi or serotonin result in …?

Answer 10

depression

Question 11

increased levels of serotonin result in …?

Answer 11

serotonin syndrome

Question 12

increased levels of acetylcholine result in …?

Answer 12

parkinson’s disease

Question 13

MAO-A is located in…?

Answer 13

liver, GI, and monaminergic neurons

Question 14

MAO-B is located in …?

Answer 14

brain and platelets

Question 15

COMT and MAO

Answer 15

enzymes that break down nor-epi and monoamine

Question 16

MAO-I block COMT and MAO and increase levels of …?

Answer 16

nor-epi, serotonin, dopamine

Question 17

excitatory neurotransmitter

Answer 17

glutamate

Question 18

induces calm and decreases electrical activity

Answer 18

GABA activation

Question 19

all antidepressants have capability of altering cardiac conduction, but which is worse?

Answer 19

tricyclics

Question 20

all antidepressants lower the seizure threshold, but which is worse?

Answer 20

bupropion

Question 21

prototypical tricyclic drug?

Answer 21

amitriptyline

Question 22

prototypical SSRI?

Answer 22

sertraline

Question 23

all SSRIs ____________ the P450 system?

Answer 23

inhibit