Pharmacology - Test 2 - Antipsychotic Flashcards
Antipsychotic
Drugs
Psychosis
mental disorder of organic and/or emotional origin; derangement of personality/loss of contact with reality
Schizophrenia
psychotic disorder characterized by disturbed thought processes, delusions, or hallucinations, in the absence of a full affective syndrome or organic mental disorder.
Affective Disorder
a disturbance of mood accompanied by related symptoms, and generally involves depression and/or elation.
Manic disorder
predominant mood is elevated, expansive or irritable, and is associated with other symptoms, such as hyperactivity, flight of ideas, inflated self-esteem, accelerated speech, and distractibility.
Major Depressive disorder
emotional state of dejection, usually associated with loss of interest in pleasure, sleep disturbances, and feelings of worthlessness or guilt, which is not a reaction to a particular environmental event
Schizophrenia: 3 symptoms
Positive, Negative, Cognitive
Target receptors of antipsychotics
Dopamine, D2 family
Two dopamine subtype families
D1, D2
D1 subtype
increase cAMP, excitatory
D2 subtype
decrease cAMP, inhibitory
Side effects of antipsychotics, due to binding of other receptors
alpha 1: orthostatic HoTN; H1 histamine: sedation; mucarinic: sedation, dry mouth; 5HT2 serotonin: aid in antipsychotic effects
BLockade of D2 causes extrapyramidal motor effects
- Parkinsonian symptoms (MOST COMMON), -Akathesia (discomfort in legs that results in walking about),
- Tardive dyskinesia (stereotyped involuntary movements)
subclass causing extrapyramidal motor side effects
typical
subclass NOT causing extrapyramidal motor side effects
atypical