Pharmacology - SIMPLIFIED Flashcards
1
Q
Vasoconstrictors
A
- oxymetazoline
- rhinitis
- causes nasal congestion
- mimics effect of NA
2
Q
H1 Receptor Antagonist
A
- anti histamine e.g loratidine
- allergic rhinitis
- drowsiness, palpititions, hypotension
- reduces effects of mast cell activation
3
Q
Omalizumab
A
- allergic asthma
- abdominal pain, pyrexia
- monoclonal antibody treatment against IgE
4
Q
Muscarinic Antagonist (M3)
A
- ipratropium, tiotropium
- COPD, rhinitis and severe asthma
- dry mouth, lack of taste, thrush, dizziness
- M3->GQ = increases PLC, which is acted on PIP2 = IP3
increased calcium (THIS IS INHIBITED)
5
Q
Cromlins
A
- cromoglycate
- allergic asthma/rhinits
- local irritation
- desensitised C ending fibres
6
Q
Corticosteroids
A
- prednisolone, beclametasone
- COPD and asthma
- cushings, diabetes, restricted growth, thrush, glaucoma
- glucocorticoid and GRA enters the nucleus…
1. annexine 1 inhibits synthesis of PLA1
2. restriction of cytokines
7
Q
Xanthines
A
- theophylline, aminophylline
- asthma
- nausea, vomit, abdo pain, headache
- inhibits PDP, which increases cAMP, decreases PKA
8
Q
CysLT1 antagonist
A
- montelukast, zafirlukast
- asthma step 4, rhinits
- headache and abdo pain
- PLA2 = mast cells, which causes release of arichodonic acid
1. stimulatoin of 5 lipoxygenase by FLAP enzyme
2. release of leukotrines which binds onto CysLT1 (DRUG STOPS BINDING)
9
Q
drugs used in asthma (6)
A
- B2 adrenoreceptor agonist
- cromlins
- omalizumab
- CysLT1 antagonist
- xanthines
- corticosteroid
10
Q
drugs used in rhinitis (6)
A
- corticosteroid
- CysLT1 antagonist
- cromlins
- muscarinic ach antagnosts of M3 receptors
- vasoconstrictors
- h1 receptor antagonist
11
Q
drugs used in copd (2)
A
- b2 adrenorecptor agonist
- muscarinic Ach antagonist of h3 receptors
