Pharmacology (Questions)

Question 1

56 y/o Woman w/ history of depression with convulsions after suicide attempt. ECG: Wide QRS complex, BP: 100/60 and 105F with dilated eyes.
provided with supportive treatment in addition to Sodium Bicarbonate. Which drug did patient most OD on

Answer 1

Nortriptyline (TCA)
Mydriasis and Hyperthermia from M block
NaBicarb ionize drug to accelerate elimination
TCA: Inhibit reuptake of 5HT and NE
Nortriptyline, Amiltriptyline, Desipramine

Question 2

Inhibit reuptake of NE, 5HT and Dopamine. Does not induce sexual SE and sedation. Also used for smoking cessation. Not for use in bulimics (Risk of seizures)

Answer 2

Bupropion

Question 3

First line treatment of depression, Anxiety and OCD. Toxicity: Sexual Dysfunction

Answer 3

SSRIs (Fluoxetine)

Question 4

Difficulty concentrating, 4 episodes in past month with daze, continuous blinking before coming out as if nothing happened. What would be the mechanism of the drug used to treat

Answer 4

Block T-Type Ca Channels
(Absence Seizure: Brief LOC followed by full recovery: MC In pediatrics)
Safe/Most effective Drug: Ethosuximide