Pharmacology Psoriasis + Acne Flashcards
name 3 calcineurin inhibitors
tacrolimus
pimecrolimus
cyclosporine
MOA calcineurin inhibitors
block cytokine production (esp IL-2)
block T-cell activation
BBW and other concerns of calcineurin inhibitors
malignancy
concern: nephrotoxic
calcipotriene drug class
vitamin D analog
tazorotene is a derivative of what
vitamin A
MOA tazarotene
PRODRUG. active form is tazarotenic acid
binds RARa, RARB, RARY (pretty selective for B and Y)
alters gene expression and suppresses hyperplasia
biggest concern with tazarotene
teratogenic
what is soriatene
a retinoid
MOA soriatene
alters gene expression - causes differentiation of keratinocytes and suppresses epidermal hyperplasia
biggest concern with soriatene
it’s a retinoid - teratogenic!
mycophenolate MOA
inhibits inosine monophosphate dehydrogenase
reduced guanine – inhibits proliferation of B and T cells
alefacept MOA
reduces # of T cells, T cell activation, causes T cell apoptosis
BINDS CD2
Ustekinumab MOA
IL-12 and IL-23 blocker
guselkumab MOA
IL-23 blocker
3 (exclusive) IL-17 blockers
ixekinumab
bodalumab
secukinumab
apremilast class
ORAL PDE4 inhibitor
MOA apremilast
PDE4 inhibitor
decreases TNFa and IL-17
increases IL-10 (anti inflam)
side effects apremilast
anorexia
GI issues
depression/suicide
name of the retinoid that’s selective for RARY
tritarotene
retinoids increase _______ and suppress _________
increase NGAL (neutrophil gelatinase associated lipocalin)
suppress hyperproliferation
azelaic acid MOA
inhibits mitochondrial oxidoreductases and 5-alpha reductase
antiproliferative and anti-dekeratinizing
which calcineurin inhibitor has highly variable GI absorption and thus needs to always be administered under the exact same conditions
cyclosporine
name some common drugs known to exacerbate acne
steroids, lithium
