Pharmacology Psoriasis + Acne

Question 1

name 3 calcineurin inhibitors

Answer 1

tacrolimus
pimecrolimus
cyclosporine

Question 2

MOA calcineurin inhibitors

Answer 2

block cytokine production (esp IL-2)
block T-cell activation

Question 3

BBW and other concerns of calcineurin inhibitors

Answer 3

malignancy

concern: nephrotoxic

Question 4

calcipotriene drug class

Answer 4

vitamin D analog

Question 5

tazorotene is a derivative of what

Answer 5

vitamin A

Question 6

MOA tazarotene

Answer 6

PRODRUG. active form is tazarotenic acid

binds RARa, RARB, RARY (pretty selective for B and Y)

alters gene expression and suppresses hyperplasia

Question 7

biggest concern with tazarotene

Answer 7

teratogenic

Question 8

what is soriatene

Answer 8

a retinoid

Question 9

MOA soriatene

Answer 9

alters gene expression - causes differentiation of keratinocytes and suppresses epidermal hyperplasia

Question 10

biggest concern with soriatene

Answer 10

it’s a retinoid - teratogenic!

Question 11

mycophenolate MOA

Answer 11

inhibits inosine monophosphate dehydrogenase

reduced guanine – inhibits proliferation of B and T cells

Question 12

alefacept MOA

Answer 12

reduces # of T cells, T cell activation, causes T cell apoptosis

BINDS CD2

Question 13

Ustekinumab MOA

Answer 13

IL-12 and IL-23 blocker

Question 14

guselkumab MOA

Answer 14

IL-23 blocker

Question 15

3 (exclusive) IL-17 blockers

Answer 15

ixekinumab
bodalumab
secukinumab

Question 16

apremilast class

Answer 16

ORAL PDE4 inhibitor

Question 17

MOA apremilast

Answer 17

PDE4 inhibitor

decreases TNFa and IL-17
increases IL-10 (anti inflam)

Question 18

side effects apremilast

Answer 18

anorexia
GI issues
depression/suicide

Question 19

name of the retinoid that’s selective for RARY

Answer 19

tritarotene

Question 20

retinoids increase _______ and suppress _________

Answer 20

increase NGAL (neutrophil gelatinase associated lipocalin)

suppress hyperproliferation

Question 21

azelaic acid MOA

Answer 21

inhibits mitochondrial oxidoreductases and 5-alpha reductase

antiproliferative and anti-dekeratinizing

Question 22

which calcineurin inhibitor has highly variable GI absorption and thus needs to always be administered under the exact same conditions

Answer 22

cyclosporine

Question 23

name some common drugs known to exacerbate acne

Answer 23

steroids, lithium