Pharmacology Of The Airways

Question 1

What two effects does delivery of medications to the lungs have on the body

Answer 1

Direct effects
Systemic effects

Or both

Question 2

Inhaled anesthetics are delivered via the lungs to act on ____ and have ____effects

Answer 2

Brain

Bronchodilatory

Question 3

Aerosolized beta adrenergic agonist work on ____ and have very few ____effects

Answer 3

Bronchial smooth muscle

Systemic

Question 4

Which system regulates airway caliber, airway glandular activity, and airway microvasculature

Answer 4

Parasympathetic

Question 5

Which nerve provides preganglionic fibers, which synapse with postgamglionic fibers in airway parasympathetic ganglia

Answer 5

Vagus

Question 6

What activated M3 receptor of postganglionic fiber

Answer 6

Acetylcholine

Question 7

When acetylcholine activated M3 receptor of postganglionic of the parasympathetic nervous system to produce “this”

Answer 7

Bronchoconstriction

Question 8

Even in the resting state what can anticholinergics provide

Answer 8

Bronchodilation

Question 9

How does beta 2 receptors present on airway smooth muscle cells cause bronchodilation

Answer 9

Via stimulatory g mechanisms

Question 10

Bronchomotor tone is influenced through nonadrenergic noncholinergic system- (NANC) what is its role

Answer 10

Excitatory and inhibitory neuropeptides that influence inflammation and smooth muscle tone- also not well understood-

Question 11

What are the main two excitatory transmitters causing bronchoconstriction and neurogenic inflammation

Answer 11

Substance P

Neurokinin A

Question 12

What are the two main inhibitory neurotransmitters causing airway smooth muscle relaxation

Answer 12

Vasoactive intestinal peptide

Nitric oxide