Alpha Receptor Antagonist (N-13) Flashcards
which agents are considered more predictable for treating emergent episodes of HTN
alpha receptor antagonist
what are alpha antagonist used for treatment
HTN BPH pheochromocytoma raynauds phenonomen ergot alkaloid toxicity
what are the side effects of alpha antagonists
orthostatic hypotension
baroreceptor-mediated reflex tachycardia
how does phenoxybenzamine bind to alpha receptors
non competitively and irreversibly
how is phenoxybenzamine effects terminated
metabolism of the drug and generation of new alpha receptors
clinically, what is phenoxybenzamine for
patients with pheochromocytoma to decrease the response to endogenous catecholamines
phenoxybenzamine can be combined with what drug during the preop treatment of pheochromocytoma
demser- (tyrosine hydroxyls inhibitor metyrosine)
what drug does phenoxybenzamine inhibit the response of
phenylephrine
what occurs when NE is given with phenoxybenzamine
NE is limited to its beta 1 agonist activity
what occurs when phenoxybenzamine is given with EPI
EPI reversal which is an enhanced Beta 2 response with a worsening of hypotension and tachycardia.
what is the primary side effect of phenoxybenzamine
orthostatic hypotension
what is frequently associated with phenoxybenzamine
nasal stuffiness
which drug is used for short term control of hypertension in patients with pheochromocytoma
phentolamine
what else is phentolamine used for outside of pheochromocytoma
treats local infiltration of vasoconstricitng agents
which drug has been noted to produce floppy iris syndrome which may complicate cataract surgery
tamsulosin
