Pharmacology of rheumatoid arthritis Flashcards
1
Q
Which enzyme does methotrexate inhibit?
A
Dihydrofolate reductase
2
Q
Methotrexate reduces the rate of synthesis of which 2 things via disruption of folate metabolism?
A
Purines
Pyrimidines
3
Q
Methotrexate promotes the release of what?
A
Adenosine
4
Q
Which enzyme does leflunomide inhibit?
A
Dihydroorotate dehydrogenase
5
Q
Infliximab binds to what?
A
TNF-a
6
Q
What is the MOA of etanercept?
A
Mimics the TNF-a receptor, serving as a “decoy receptor” to soak up soluble TNF-a
