Drugs List

Question 1

Which 2 drugs are bisphosphonates?

Answer 1

Alendronate

Pamidronate

Question 2

What is the MOA of bisphosphonates?

Answer 2

Promotion of osteoclast apoptosis and inhibition. Reduction of calcium release from bone. Inhibits farnesyl pyrophosphate synthase enzymes (FPPS)

Question 3

What is the key side effect of bisphosphonates?

Answer 3

Oesophagitis

Question 4

Which drug is a selective oestrogen receptor modulator?

Answer 4

Raloxifene

Question 5

What is the MOA of selective oestrogen receptor modulators?

Answer 5

Activates oestrogen receptors in osteoblasts to retain bone mineralisation

Question 6

Which drug is a biologic (monoclonal antibody) for osteoporosis treatment?

Answer 6

Denosumab

Question 7

What is the MOA of biologics (monoclonal antibody) for osteoporosis?

Answer 7

Inhibition of RANKL, inhibition of osteoclast activity and bone resorption

Question 8

Which 2 drugs are DMARDs used to treat rheumatoid arthritis?

Answer 8

Methotrexate

Leflunomide

Question 9

What is the MOA of methotrexate?

Answer 9

Reduces purines and pyrimidines by inhibiting dihydrofolate reductase

Increases adenosine production

Question 10

What is the MOA of leflunomide?

Answer 10

Reduces pyrimidines by inhibiting dihydroorotate dehydrogenase

Question 11

What is the MOA of infliximab?

Answer 11

Blocks TNF-a

Question 12

What is the MOA of etanercept?

Answer 12

Decoy TNF-a receptor

Question 13

What is the key side effect of infliximab and etanercept?

Answer 13

Increased infection risk

Question 14

Which drug is used to treat Myasthenia Gravis?

Answer 14

Pyridostigmine

Question 15

What is the MOA of pyridostigmine?

Answer 15

Inhibition of enzymatic breakdown of ACh

Question 16

Which 3 drugs are beta lactams - penicillins?

Answer 16

Flucloxacillin
Benzylpenicillin
Amoxicillin / co-amoxiclav

Question 17

What is the MOA of beta lactams - penicillins?

Answer 17

Bactericidal

Question 18

What is the key side effect of beta lactams - penicillins?

Answer 18

Hypersensitivity

Question 19

Which drug is a beta lactams - carbapenems?

Answer 19

Meropenem

Question 20

What is the MOA of meropenem?

Answer 20

Bactericidal

Question 21

Which drug is a cephalosporin?

Answer 21

Ceftriaxone

Question 22

What is the MOA of ceftriaxone?

Answer 22

Bactericidal

Question 23

Which drug is a fluoroquinolone?

Answer 23

Ciprofloxacin

Question 24

What is the MOA of ciprofloxacin?

Answer 24

Bacteriostatic - inhibition of bacterial DNA coiling

Question 25

What is the key side effect of ceftriaxone and ciprofloxacin?

Answer 25

Risk of C. Difficile infection

Question 26

Which drug is a lincosamide?

Answer 26

Clindamycin

Question 27

What is the MOA of clindamycin?

Answer 27

Bacteriostatic - inhibition of bacterial protein synthesis

Question 28

Which drug is a macrolide?

Answer 28

Erythromycin

Question 29

What is the MOA of erythromycin?

Answer 29

Bacteriostatic - inhibition of bacterial protein synthesis

Question 30

Which 2 drugs are tetracyclines?

Answer 30

Tetracycline Doxycycline

Question 31

What is the MOA of tetracyclines?

Answer 31

Bacteriostatic - inhibition of bacterial protein synthesis

Question 32

Which drug is an anti-folate antibiotic?

Answer 32

Trimethoprim

Question 33

What is the MOA of trimethoprim?

Answer 33

Bacteriostatic – inhibition of bacterial folic acid synthesis, which affects bacterial DNA synthesis

Question 34

Which antibiotic should be used with caution in pregnancy?

Answer 34

Trimethoprim