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Mechanisms of Drug Action > Pharmacology of Peripheral Neural Transmission > Flashcards

Pharmacology of Peripheral Neural Transmission Flashcards

1
Q

α-latrotoxin

A

Binds neurexins

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2
Q

α-methyldopa

A

α adrenoceptor agonist
(α1 < NA)
(α2 > NA)

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3
Q

Amitriptyline

A

Uptake 1 inhibitor

Tricyclic antidepressant

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4
Q

Atenolol

A

Selective β1 R antagonist

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5
Q

Adenosine triphosphate

A

Purinoceptor agonist

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6
Q

Atracurium

A

Competitive NMJ nicotinic cholinergic R agonist

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7
Q

Atropine

A

Non-selective muscarinic cholinergic R antagonist

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8
Q

Bethanechol

A

Non-selective muscarinic cholinergic R agonist

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9
Q

Botulinum toxins

A

SNARE proteins inhibitor

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10
Q

β-bungarotoxin

A

Acetylcholine vesicle release inhibitor

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11
Q

Butaxamine/butoxamine

A

Selective β2 adrenoceptor antagonist

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12
Q

Caffeine

A

Non-selective A1 & A2 R antagonist

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13
Q

Carbidopa

A

DOPA decarboxylase inhibitor

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14
Q

Clonidine

A

α (2 > 1) adrenoceptoragonist

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15
Q

Clorgiline

A

Selective monoamine oxidase A inhibitor

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16
Q

Cocaine

A

Uptake 1 inhibitor

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17
Q

D-amphetaime/dexamphetamine

A

Displaces NA from vesicles
Adrenoceptor agonist
Competes for uptake 1
Weak MAO I

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18
Q

Darifeneacin

A

Selective M3 muscarinic cholinergic R antagonist

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19
Q

Dipyridamole

A

Type V phosphodiesterase

Blocks adenosine reuptake

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20
Q

Dobutamine

A

Selective β1 adrenoceptor agonist

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21
Q

D-tubocurarine/curare/tubocurarine

A

Non-selective nicotinic cholinergic R antagonist

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22
Q

Dyflos

A

Irreversible, long lasting cholinesterase inhibitor

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23
Q

Edrophonium

A

Reversible, short acting cholinesterase inhibitor

24
Q

Entacapone

A

Catechol o-methyltransferase (COMT) inhibitor

25
Q

Guanethidine

A

Competitive uptake 1 inhibitor

26
Q

Hemicholinium

A

Choline uptake inhibitor

27
Q

Hexamethonium

A

Non-selective ganglion blocker

28
Q

Idazoxan

A

Selective α2 adrenoceptor antagonist

29
Q

Imipramine

A

Uptake 1 blocker

Tricyclic antidepressant

30
Q

Isoprenaline

A

Non-selective β-adrenoceptor agonist

10x > A

31
Q

Labetalol

A

Non-selective α1 & β adrenoceptor antagonist

α1 < β

32
Q

L-NMMA

A

Non-selective nitric oxide synthase inhibitor

33
Q

Malathion

A

Irreversible, long acting cholinesterase inhibitor

34
Q

Mecamylamine

A

Non-selective, ganglion nicotinic cholinergic R antagonist of the open channel (use-dependent)

35
Q

Muscarine

A

Muscarinic cholinergic R agonist

36
Q

Neostigmine

A

Reversible cholinesterase inhibitor

37
Q

Nicotine

A

Nicotinic cholinergic R agonist

ganglia > NMJ

38
Q

Nitroglycerin

A

Nitrovasodilator

39
Q

Pancuronium

A

Competitive NMJ nicotinic cholinergic R antagonist

40
Q

Phentolamine

A

Non-selective α1 & β1 adrenoceptor

41
Q

Phenylephrine

A

α1 & β1 adrenoceptor agonist

α1&raquo_space; β1

42
Q

Pilocarpine

A

Non-selective muscarinic cholinergic R agonist

43
Q

Pralidoxime

A

Reverses acetyl cholinesterase inhibition

44
Q

Prazosin

A

Selective α1 adrenoceptor antagonist

45
Q

Propranolol

A

β-blocker

46
Q

Reserpine

A

Vesicular monoamine transport 2 inhibitor

47
Q

Salbutamol

A

Selective β2 adrenoceptor agonist

48
Q

Selegiline

A

Monoamine oxidase B inhibitor

49
Q

Sildenafil

A

Phosphodiesterase V inhibitor

50
Q

Suxamethonium

A

NMJ nicotinic cholinergic R antagonist

51
Q

Tetanus toxin

A

Synaptobrevin inhibitor

52
Q

Tranylcypromine

A

Non-selective monoamine oxidase inhibitor

53
Q

Tyramine

A

Displaces NA from the vesicle

Adrenoceptor agonist

54
Q

Vesamicol

A

Non-competitive, reversible acetylcholine transporter into the vesicle inhibitor

55
Q

Xylazine

A

Selective α2 adrenoceptor agonist

Mechanisms of Drug Action (2 decks)

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