Pharmacology of Obesity - Martin Flashcards
drug tx of obesity
modest efficacy
adverse side effect
low adherence
regain weight when drug stopped
phentermine/topiramate ER
sympathomimetic amine/antiepileptic combo
phentermine - sympathomimetic
topiramate - tx epilepsy and migraine
combo - recently FDA approved for obesity
Ci phentermin/toporamate ER
pregnancy
schedule IV controlled substance
most efficacious weight loss drug
phentermine/toporamate ER
- 260 to 230 lbs over 56 weeks
- really that good?
orlistat
lipase inhibitor
pancreatic and gastric lipase inhibitor - decreased absorption of fat from GI tract
adverse orlistate
flatulence
oily spotting
fecal urgency
CI - pregnancy
lorcaserin
serotonin receptor agonist
selective serotonin 2C agonist - suppress appetite
adverse lorcaserin
schedule IV drug
HA, nausea, dizzy
CI in pregnancy
don’t take with MAOIs, SSRIs, SNRIs
lorcarserin
bupropion/naltrexone
bupropion - antidepressant - smoking cessation
naltrexone - opioid receptor antagonist
combo - contrave
bupropion appetite suppressant - potentiated by naltrexone
adverse of bupropion/naltrexone
vomiting, nausea, constipation, dizzy, dry mouth
CI in pregnancy
liraglutide
GLP-1 agonist
glucagon like peptide 1
-to tx type 2 diabetes also
liraglutide MOA
slow gastric emptying
-GLP-1 agonist
decreased rate of absorption of other drugs
black box warning thyroid C cell tumor
liraglutide - saxenda
metformin
modest weight loss compared to sulfonylurea
tx of DM
significant and sustained weight loss
