Pharmacology of Non-Targeted Chemotherapies

Question 1

Vincristine

Answer 1

Type: Vinca-Alkaloid

MOA: inhibit microtubule polymerization

AE:
1. General AES (GI, BM, Hair)
2. Neurotoxic (peripheral neuropathy; most important
3. Extravasation (monitor for pain, swelling, poor blood return)
4. Constipation (given with laxatives and stool softeners)

Question 2

Vinblastine

Answer 2

Type: Vinca-Alkaloid

MOA: inhibit microtubule polymerization

AE:
1. General AES (GI, BM, Hair)
2. Neurotoxic (peripheral neuropathy)
3. Extravasation (monitor for pain, swelling, poor blood return)
4. Myelotoxic (vinBLASTine decreases blasts)

Question 3

Pacitaxel

Answer 3

Type: Taxan

MOA: inhibit microtubule depolymerization

AE:
1. General AES (GI, BM, Hair)
2. Neurotoxic (peripheral neuropathy; most important
3. Anaphylaxis (premedication with corticosteroids and antihistamines)

Question 4

Docetaxel

Answer 4

Type: Taxan

MOA: inhibit microtubule depolymerization

AE:
1. General AES (GI, BM, Hair)
2. Neurotoxic (peripheral neuropathy)
3. Anaphylaxis (premedication with corticosteroids and antihistamines)
4. Fluid retention (premedication with corticosteroid)