Monoclonal Antibodies (mAb)

Question 1

Cetuximab

Answer 1

Type: EGFR Target

MOA: mAb to EGFR
–> EGFR signaling targets TRMP6

AE:
1. Rash
2. GI AE
3. Hypomagnesemia

Question 2

Trastuzumab

Answer 2

Type: Targeting HER-2

MOA: mAb against HER-2

AE:
1. Cardiotoxic

Question 3

Bevacizumab

Answer 3

Type: Targeting VEGFR

MOA: mAb to VEGFR

AE:
1. HTN*
2. Thromboembolism*
3. Poor wound healing

*Class effects on VEGFR targeted drugs