pharmacology of influenza Flashcards
amantadine MOA and anti-viral spectrum
blocks viral M2 ion (H+) channel, prevents uncoating
-influenza A only
what are the neuraminidase inhibitors
mavir and mivir
oseltamivir
zanamavir
oseltamivir and zanamavir treat
influenza A and B
which neuroaminadase inhibitor is oral and which is inhaled
oral = oseltamivir inhaled = zanamavir (not recommended with lung problems)
which NA Inhibitor is approved for 1 year and older
oseltamivir
which NA inhibtitor is used to treat 7 year olds and above and prevent flu in 5 year olds and older
zanamivir
NAI need to be admiistered within ___ hours of symptoms appearing
less than 48
amantadine not recommended for
antiviral treatment of chemoprophylazis of currently circulating influenza A virus strains
enzyme for first step in nucleoside phosphorylation in HSV and by cell or virus, next enzyme
thymidine kinase, virus
GMP kinase, host cell
what is the black box warning for NRTIs and what enzyme is inhibited
lactic acidosis syndrome
mDNA polymerase y
rank order of inhibition of mt DNA pol y with NRTIs
didanosine> stavudine> zidovudine
which NRTI causes pancreatitis
stavudine
which NRTIs cause neuropathy
stavudine and didanosine
which NRTIs cause lipoatrophy and lipodystrophy
all of them
which NRTIs cause lactic acidosis and hepatic steatosis
didanosine, stavudine, zidovudine
