Anti-fungals Flashcards
what enzymes to azoles inhibit
lanosterol 14-a-demethylase
flucanzole is narrow or broad spectrum and treats what
narrow
candida albicans
cryptococcus
which of the azoles has a renal clearance and is used to treat kidney infection
flucanozole
fungal resistance to azoles
mutation in lanesterol 14-a-demethylase or overexpression of it
MOA of echinocandins
B 1,3 glucan synthase inhibition
caspofungin treats what opportunisitc infections
invasive candidiasis
invasive aspergillosis
are echinocandins effective aginast pathogenic fungal organisms?
no
histo
coccidio
fusarium
is itraconazole borad spectrum or nah?
yes
covers candida and some activity vs apergillus
mainly for histo, coccidio, blasto
which drug class requires a low pH to be active and is not effective with PPIs
ketoconazole and all other azoles
which azoles have excellent distribution into the CSF
voriconazole
fluconazole
are triazoles safe in pregnancy?
no
also can damage liver
what is the drug of choice for mucormycosis
amphotericin B
what can be mutated to prevent 5-FC from entering cell
cytosine permease
or cytosine deaminase
what enzyme is inhibitied by 5-FC when it gets converted to ____ then 5-dUMP
when converted to anther form (____) what does it inhibit
5-FU
thymidylate synthase
-inhibits DNA synthesis
when converted to FUTP inhibits protein syn
when is oral terbinafine contra-indicated
in pregnancy
