Pharmacology of COPD

Question 1

Targeting Muscarinic receptors -

Answer 1

airway smooth muscle contraction

Question 2

M1 -

Answer 2

facilitate fast neurotransmission mediated by ACh acting on nicotinic receptors into lung

Question 3

where is M2 located -

Answer 3

located in postganglionic neuron area, inhibitory autoreceptors reducing release of ACh

Question 4

what does M2 DO

Answer 4

• Opposite signalling to M1 and M3
• blocking M2 increases Ach release

Question 5

• M3

Answer 5

• airway smooth muscle, mediate contraction to Ach
  
  • drugs focus on M3

Question 6

Chronic bronchitis

Answer 6

• inflammation of bronchi and bronchioles
• cough
• clear mucoid sputum
• infections with purulent sputum
• increasing breathlessness

Question 7

Emphysema

Answer 7

• distension and damage to alveoli
• destruction of acinial pouching in alveolal sacs
• loss of elastic recoil

Question 8

competitive muscarinic receptor antagonists

Answer 8

SABA and LAMA
eg.
Ipratropium

Tiotropium
Glycopyrronium
Aclidinium
Umeclidinium

Question 9

adverse effect of drugs

Answer 9

Increases chance of bacteria growing in mucus glands, should be given with antibiotics (check COPD notion for antibiotic)