Pharmacology - Multiple Sclerosis/neuroprotectants for stroke

Question 1

**fingolimod MOA

Answer 1

blocks the ability of lymphocytes to leave the lymph node – minimizing damage to the myelin sheath bc the lymphcytes dont enter the CNS

Question 2

*fingolimod-phosphate initially ______ via ______ and later…..

Answer 2

initially activates lymphocyte S1P1 (sphingosine-1 phosphate) via HIGH-AFFINITY receptor binding

later, S1P1 down regulation prevents the egress of lymphocytes from the lymph node

Question 3

*laquinimod:

inhibits ____
activates ____
causes ___osis
causes apoptosis of ___
decreases ___ factors

Answer 3

inhibitrs demyelination

microglial activation

apoptosis of oligodendrocytes

decreases proinflammatory factros

Question 4

*name 4 neuroprotectants for stroke

Answer 4

CCB
glutamate antagonists

edaravone
cerebrolysin

Question 5

*how is edaravone a neuroprotectant for stroke

Answer 5

free radical scavenger

Question 6

*how is cerebrolysin a neuroprotectant for stroke

Answer 6

counteracts excitotoxicity

reduces free radicals and inflammatory reactions. reduces apoptosis

Question 7

*cerebrolysin activates ____ pathways

Answer 7

regeneration