Pharmacology - Alzheimer's/ Huntington's Chorea Flashcards
1
Q
name 4 ACHEI and a common side effect
A
donepezil
rivastigmine
galantamine
tacrine
decreased appetite and weight loss
2
Q
*MOA tacrine (cognex)
A
ACHE inhibitor AND BuChEI inhibitor (butyryl cholinesterase inhibitor)
3
Q
*donepezil MOA
A
ACHE inhibitor
4
Q
*rivastigmine MOA
A
ACHEI and BUCHEI inhibtior
5
Q
*moa galantamine
A
DUAL MOA
ACHEI
allosteric nicotinic modulation
6
Q
*memantine MOA
A
noncompetitive open channel NMDA receptor antagonist
-thus, prevents glutamate from acting on this receptor
7
Q
*memantine has a preference for….
A
NMDA receptor-operated cation channels
8
Q
*true or false
memantine is a competitive inhibitor of NMDA receptor
A
false - noncompetitive
9
Q
*2 Drugs for Huntington’s chorea and their half lives
A
tetrabenazine 5-6 hours
deutetrabenazine 17 hours - QD dosing
10
Q
A
