Pharmacology Key Drugs Flashcards
ACh
Non-selective agonist for nicotinic and muscarinic receptors
Pilocarpine, Muscarine
Selective muscarinic agonist
Methacholine, Bethanechol
Selective muscarinic agonist
Atropine
Muscarinic antagonist
Hyoscine, Ipratropium, Tiotropium
Muscarinic antagonist
Nicotine
Selective nicotinic agonist
Hexamethonium
Selective nicotinic antagonist
Ergot Alkaloids
Monoamine antagonists/ partial agonists
Noradrenaline
a1 and b1 adrenoceptor agonist
Phenylephrine, Methoxamine
a1 adrenoceptor agonist
Brimonidine
a2 adrenoceptor agonist
Dobutamine
b1 adrenoceptor agonist
Salbutamol, Salmeterol
b2 adrenoceptor agonist
Mirabegron
b3 adrenoceptor agonist
Procainamide, Quinidine, Disopyramide
Class 1a Na+ channel blockers
- moderate block
- slow AP rise
- slow repolarisation
Lidocaine, Mexilitine, Tocainide, Phenytoin
Class 1b Na+ channel blockers
- associate + dissociate rapidly
- selective to inactivated channels
- slow AP rise
- faster repolarisation
Flecainide, Encainide
Class 1c Na+ channel blockers
- associate + dissociate slowly
- slow AP rise
- same repolarisation
Propranolol, Alpreolol, Metoprolol
Class II b-blockers
- block b1 receptors
- reduce slow inward Ca2+ current of pacemaker potential
- reduce SAN activity
- slow AV conduction
Amiodarone, Sotalol
Class III K+ channel blockers
- prolong cardiac AP
- increase refractory period
- reduces time window for dysrhythmias
Verapamil, Diltiazem
Class IV Ca2+ channel blockers
- decrease SAN excitability
- slow AP rise
- decrease AVN conduction
Digoxin
Cardiac glycoside
- blocks Na+/K+ ATPase
- slow AVN conduction
Adenosine
- activates A1 receptors
- potent AVN conduction blocker
