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Renal, Hematological, and Cardiovascular Organ Systems > Pharmacology- hematologic Malignancies > Flashcards

Pharmacology- hematologic Malignancies Flashcards

1
Q

What is the significant toxicity of Arsenic Trioxide?

A

Acute promyelocytic leukemia differentiation syndrome, AV block, cardiac arrhythmias, leukocytosis

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2
Q

What is the toxicity of Asparaginase L-Asparaginase PPegaspargase?

A

Hypersensitivity, Hypersensitivity to product of E. Coli, or Erwinia, Bleeding (decreased fibrinogen, protein C activity, protein S activity, and anti-thrombin III). Glucose Intolerance

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3
Q

What is the drug Toxcity of ATRA?

A

Acute promyelocytic leukemia differnentiation syndrome, leukocytosis

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4
Q

What is the drug toxicity of Bendamustine?

A

infusion reactions, elevated liver enzymes, hyperuricemia

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5
Q

What is the drug toxicity of corticosteroids like dexamethasone?

A

indigestion or heartburn, ingestion or heartburn, increased apetite and weight gain, water retention, increased risk of infection, fluctuation in blood sugar levels, changes in mood and behavior, difficulty sleeping

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6
Q

What is the drug toxicity of Bleomycin?

A

idiosyncratic reaction to bleomycin (fever), pulmonary fibrosis

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7
Q

What is the drug toxicity of Busulfan?

A

Bone marrow suppression, secondary malignancies

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8
Q

What is the drug toxicity of Carboplatin ?

A

platinum hypersensity, bone marrow suppressin, **anemia, infection **

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9
Q

What is the drug toxicity of Chlorambucil?

A

Bone marrow suppression, secondary malignancy, pregancy, infertility

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10
Q

What is the drug toxicity of Cladribine?

A

Bone marrow supprssion, nephron- and neurotoxicity

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11
Q

What is the drug toxicity of Clofarabine?

A

Bone marrow suppression, opportunisitc infection

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12
Q

What is the drug toxicity of Cytarabine, ARA-C?

A

Bone marrow suppression, opportunistic infection

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13
Q

What is the drug toxicity of Cyclophosphamidee?

A

Anaphylaxis, myelosuppressin, renal compromise, hemorrhagic cystitis

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14
Q

What is the drug toxicity of Ifosfamide?

A

Bone marrow suppression, coma, renal compromise, hemorrhagic cystitis

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15
Q

What is the drug toxicity of Dacarbazine?

A

bone marrow suppression, hepatic disease, pregnancy, secondary malignancy

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16
Q

What is the drug toxicity of Daunorubicin? Doxorubicin? Idarubicin?

A

Bone marrow suppression, heart disease, hepatic disease, secondary maligancies, extravasational necrosis

17
Q

What is the drug toxicity of Etoposide?

A

Meylosuppression, bleeding, opportunistic infection

18
Q

What is the drug toxicity of Teniposide?

A

Hypersensitivity reactions, **bone marrow suppression **

19
Q

What is the drug toxicity of Fludarabine?

A

Bone marrow suppression, coma, seizures, don’t give with pentostatin

20
Q

What is the drug toxicity of Hydroxyurea?

A

mutagenic, teratogenic, secondary malignancies

21
Q

What is the drug toxicity of Interferon Alpha-2b?

A

**Contraindicated with autoimmune disease, cardiac disease; increased suicidal ideation, depression **

22
Q

What is the drug toxicity of Mechlorethamine?

A

Bone marrow suppression, extravasation, pregnancy

23
Q

What is the drug toxicity of Methotrexate?

A

Ascities, diarrhea, exfoliative dermatitis, infection, lymphoma, pulmonary disease, pulmonary fibrosis, renal impairment, stomatitis, tumor lysis syndrome (TLS)

24
Q

What is the drug toxicity of Mercaptopurine?

A

Bone Marrow suppression; TMPT genotyping

25
Q

What is the drug toxicity of Mitoxantrone?

A

Extravasation, heart failure, intrathecal administration, neutropenia, secondary malignacy

26
Q

What is the drug toxicity of Pentostatin?

A

Hepatic disease, pulmonary deema, renal failure, seizures, use with fludarabine

27
Q

What is the drug toxicity of Procarbazine?

A

Myelosuppression, bleeding, opportunisitic infection

28
Q

What is the drug toxicity of Thioguanine, 6-TG?

A

Bone marrow suppression; TPMT genotyping

29
Q

What is the drug toxicity of Vinvlastine, Vincristine?

A

Extravasation, intrathecal administration-FATAL!! neuropathic toxicity

30
Q

What is the drug toxicity of Alemtuzumab?

A

Bone marrow suppression, infection, infusion reaction

31
Q

What is the drug toxicity of Dasatinib [Sprycel]?

A

Bone marrow suppression, fluid retention

32
Q

What is the drug toxicity of Gemtuxumab/ Ozogamicin?

A

**Bone marrow suppression, hepatic & pulmonary diseasez, infusion reaction **

33
Q

What is the drug toxicity of Imatinib?

A

Birth defects, bone marrow suppression

34
Q

What is the drug toxicity of Nilotinib?

A

**Contraindicated in hypo-kalemia & magnesemia; QT prolongation **

35
Q

What is the drug toxicity of Ibritumonmab, Tiuxetan?

A

**Bone marrow suppression, exfoliate dermatitis, infusion reaction **

36
Q

What is the drug toxicity of Tosilumomab?

A

Iodine hypersenstitivity, thrombocytopenia, neutropenia

37
Q

What is the drug toxicity of Rituximab?

A

Exfoliate dermatitis, infusion reaction, progressive multifocal leukoencephalopathy

38
Q
A

Renal, Hematological, and Cardiovascular Organ Systems (9 decks)

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