Pharmacology- hematologic Malignancies Flashcards
What is the significant toxicity of Arsenic Trioxide?
Acute promyelocytic leukemia differentiation syndrome, AV block, cardiac arrhythmias, leukocytosis
What is the toxicity of Asparaginase L-Asparaginase PPegaspargase?
Hypersensitivity, Hypersensitivity to product of E. Coli, or Erwinia, Bleeding (decreased fibrinogen, protein C activity, protein S activity, and anti-thrombin III). Glucose Intolerance
What is the drug Toxcity of ATRA?
Acute promyelocytic leukemia differnentiation syndrome, leukocytosis
What is the drug toxicity of Bendamustine?
infusion reactions, elevated liver enzymes, hyperuricemia
What is the drug toxicity of corticosteroids like dexamethasone?
indigestion or heartburn, ingestion or heartburn, increased apetite and weight gain, water retention, increased risk of infection, fluctuation in blood sugar levels, changes in mood and behavior, difficulty sleeping
What is the drug toxicity of Bleomycin?
idiosyncratic reaction to bleomycin (fever), pulmonary fibrosis
What is the drug toxicity of Busulfan?
Bone marrow suppression, secondary malignancies
What is the drug toxicity of Carboplatin ?
platinum hypersensity, bone marrow suppressin, **anemia, infection **
What is the drug toxicity of Chlorambucil?
Bone marrow suppression, secondary malignancy, pregancy, infertility
What is the drug toxicity of Cladribine?
Bone marrow supprssion, nephron- and neurotoxicity
What is the drug toxicity of Clofarabine?
Bone marrow suppression, opportunisitc infection
What is the drug toxicity of Cytarabine, ARA-C?
Bone marrow suppression, opportunistic infection
What is the drug toxicity of Cyclophosphamidee?
Anaphylaxis, myelosuppressin, renal compromise, hemorrhagic cystitis
What is the drug toxicity of Ifosfamide?
Bone marrow suppression, coma, renal compromise, hemorrhagic cystitis
What is the drug toxicity of Dacarbazine?
bone marrow suppression, hepatic disease, pregnancy, secondary malignancy
What is the drug toxicity of Daunorubicin? Doxorubicin? Idarubicin?
Bone marrow suppression, heart disease, hepatic disease, secondary maligancies, extravasational necrosis
What is the drug toxicity of Etoposide?
Meylosuppression, bleeding, opportunistic infection
What is the drug toxicity of Teniposide?
Hypersensitivity reactions, **bone marrow suppression **
What is the drug toxicity of Fludarabine?
Bone marrow suppression, coma, seizures, don’t give with pentostatin
What is the drug toxicity of Hydroxyurea?
mutagenic, teratogenic, secondary malignancies
What is the drug toxicity of Interferon Alpha-2b?
**Contraindicated with autoimmune disease, cardiac disease; increased suicidal ideation, depression **
What is the drug toxicity of Mechlorethamine?
Bone marrow suppression, extravasation, pregnancy
What is the drug toxicity of Methotrexate?
Ascities, diarrhea, exfoliative dermatitis, infection, lymphoma, pulmonary disease, pulmonary fibrosis, renal impairment, stomatitis, tumor lysis syndrome (TLS)
What is the drug toxicity of Mercaptopurine?
Bone Marrow suppression; TMPT genotyping
What is the drug toxicity of Mitoxantrone?
Extravasation, heart failure, intrathecal administration, neutropenia, secondary malignacy
What is the drug toxicity of Pentostatin?
Hepatic disease, pulmonary deema, renal failure, seizures, use with fludarabine
What is the drug toxicity of Procarbazine?
Myelosuppression, bleeding, opportunisitic infection
What is the drug toxicity of Thioguanine, 6-TG?
Bone marrow suppression; TPMT genotyping
What is the drug toxicity of Vinvlastine, Vincristine?
Extravasation, intrathecal administration-FATAL!! neuropathic toxicity
What is the drug toxicity of Alemtuzumab?
Bone marrow suppression, infection, infusion reaction
What is the drug toxicity of Dasatinib [Sprycel]?
Bone marrow suppression, fluid retention
What is the drug toxicity of Gemtuxumab/ Ozogamicin?
**Bone marrow suppression, hepatic & pulmonary diseasez, infusion reaction **
What is the drug toxicity of Imatinib?
Birth defects, bone marrow suppression
What is the drug toxicity of Nilotinib?
**Contraindicated in hypo-kalemia & magnesemia; QT prolongation **
What is the drug toxicity of Ibritumonmab, Tiuxetan?
**Bone marrow suppression, exfoliate dermatitis, infusion reaction **
What is the drug toxicity of Tosilumomab?
Iodine hypersenstitivity, thrombocytopenia, neutropenia
What is the drug toxicity of Rituximab?
Exfoliate dermatitis, infusion reaction, progressive multifocal leukoencephalopathy
